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Titolo:
HIPPOCAMPAL ACETYLCHOLINE-RELEASE DURING MEMORY TESTING IN RATS - AUGMENTATION BY GLUCOSE
Autore:
RAGOZZINO ME; UNICK KE; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,LIFE SCI LABS,GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL,LIFE SCI LABS CHARLOTTESVILLE VA 22903
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 10, volume: 93, anno: 1996,
pagine: 4693 - 4698
SICI:
0027-8424(1996)93:10<4693:HADMTI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS MAGNOCELLULARIS; AFFINITY CHOLINE UPTAKE; MEDIAL SEPTAL AREA; SPONTANEOUS-ALTERNATION; INVIVO MICRODIALYSIS; OPIATE RECEPTORS; ACETYL-COA; BRAIN; INJECTIONS; CORTEX;
Keywords:
CHOLINERGIC; LEARNING; HIPPOCAMPUS; MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Ragozzino et al., "HIPPOCAMPAL ACETYLCHOLINE-RELEASE DURING MEMORY TESTING IN RATS - AUGMENTATION BY GLUCOSE", Proceedings of the National Academy of Sciences of the United Statesof America, 93(10), 1996, pp. 4693-4698

Abstract

Several lines of evidence indicate that a modest increase in circulating glucose levels enhances memory. One mechanism underlying glucose effects on memory may be an increase in acetylcholine (ACh) release. The present experiment determined whether enhancement of spontaneous alternation performance by systemic glucose treatment is related to an increase in hippocampal ACh output. Samples of extracellular ACh were assessed at 12-min intervals using in vivo microdialysis with HPLC-EC. Twenty-four minutes after an intraperitoneal injection of saline or glucose (100, 250, or 1000 mg/kg), rats were tested in a four-arm cross maze for spontaneous alternation behavior combined with microdialysis collection. Glucose at 250 mg/kg, but not 100 or 1000 mg/kg, produced an increase in spontaneous alternation scores (69.5%) and ACh output (121.5% versus baseline) compared to alternation scores (44.7%) and ACh output (58.9% versus baseline) of saline controls. The glucose-inducedincrease in alternation scores and ACh output was not secondary to changes in locomotor activity. Saline and glucose (100-1000 mg/kg) treatment had no effect on hippocampal ACh output when rats remained in theholding chamber. These findings suggest that glucose may enhance memory by directly or indirectly increasing the release of ACh. The results also indicate that hippocampal ACh release is increased in rats performing a spatial task Moreover, because glucose enhanced ACh output only during behavioral testing, circulating glucose may modulate ACh release only under conditions in which cholinergic cells are activated.

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Documento generato il 14/08/20 alle ore 16:54:37