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Titolo:
RESPIRATORY-CHAIN ENZYME-ACTIVITIES IN ISOLATED-MITOCHONDRIA OF LYMPHOCYTES FROM UNTREATED PARKINSONS-DISEASE PATIENTS
Autore:
MARTIN MA; MOLINA JA; JIMENEZJIMENEZ FJ; BENITOLEON J; ORTIPAREJA M; CAMPOS Y; ARENAS J; ALVAREZCERMENO JC; ARCAYA J; AYUSOPERALTA L; BALSEIRO J; BERMEJO F; CAMINERO A; CATALAN MJ; CEBALLOS A; DOMINGO J; DUARTE J; FERNANDEZCARRIL JM; GALIANO M; GARCIARUIZ PJ; GARCIAURRA D; GIMENEZROLDAN S; GRANDAS F; LOPEZLOZANO JJ; LUENGO A; MARCO J; MARSAL C; MARTINEZMARTIN P; MATEO D; MUNOZVAZQUEZ A; NOS J; PEREZSEMPERE A; PONDALSORDO M; PUENTESGIL JM; RABASA M; RALLOGUTIERREZ B; RIVAMEANA C; RUIZEZQUERRO JJ; SANCHEZALONSO P; SANCHEZPERNAUTE R; TABERNERO C; VAAMONDE J; VAQUEZ A; VELADESOJO L; VIVANCOSMATELLANO F; DEYEBENES JG; YUSTA A;
Indirizzi:
C CORREGIDOR JOSE PASAMONTE 24,3-D E-28030 MADRID SPAIN HOSP UNIV DOCE OCTUBRE,DEPT BIOCHEM ALCALA DE HENARES MADRID SPAIN HOSP UNIV DOCE OCTUBRE,DEPT NEUROL ALCALA DE HENARES MADRID SPAIN HOSP UNIV PRINCIPE ASTURIAS,DEPT NEUROL ALCALA DE HENARES MADRID SPAIN
Titolo Testata:
Neurology
fascicolo: 5, volume: 46, anno: 1996,
pagine: 1343 - 1346
SICI:
0028-3878(1996)46:5<1343:REIIOL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX-I DEFICIENCY; SKELETAL-MUSCLE; BRAIN; INHIBITION; 1-METHYL-4-PHENYLPYRIDINIUM; ABNORMALITIES; METABOLITE; OXIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Martin et al., "RESPIRATORY-CHAIN ENZYME-ACTIVITIES IN ISOLATED-MITOCHONDRIA OF LYMPHOCYTES FROM UNTREATED PARKINSONS-DISEASE PATIENTS", Neurology, 46(5), 1996, pp. 1343-1346

Abstract

We studied respiratory-chain enzyme activities in lymphocyte mitochondria from 36 untreated Parkinson's disease (PD) patients and in 30 age- and sex-matched healthy controls. The respiratory-chain enzyme activities did not differ significantly between patients and controls. Moreover, no patient showed respiratory-chain enzyme levels below normal range. Values for activities of complexes in the PD group did not correlate with age at onset, duration, scores of the Unified Parkinson's Disease Rating scales, or Hoehn and Yahr staging. These results suggest that the presence of defects of respiratory-chain complexes could depend on methodologic aspects, and that determinations of respiratory-chain enzymes in cell homogenates are not generally appropriate for evaluating abnormal mitochondrial dysfunction, especially when the amount of the specific enzyme is relatively low, as is the case of blood cells. In addition, the method of measuring complex I activity is critical for evaluating the results. In conclusion, our finding of normal mitochondrial function in lymphocyte mitochondria suggests that this tissuecannot be used to develop a diagnostic test for PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:04:39