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Titolo:
SIGNIFICANCE OF SERUM LIPASE IN PATIENTS UNDERGOING HEMODIALYSIS
Autore:
SHIBASAKI T; MATSUDA H; OHNO I; GOMI H; NAKANO H; MISAWA T; ABE S; ISHIMOTO F; KISUGI R; IKEDA K; MACHIDA K; SAKAI O;
Indirizzi:
JIKEI UNIV,SCH MED,DEPT INTERNAL MED 2,MINATO KU,3-25-8 NISHI SHIMBASHI TOKYO 105 JAPAN JIKEI UNIV,SCH MED,CENT CLIN LAB TOKYO 105 JAPAN
Titolo Testata:
American journal of nephrology
fascicolo: 4, volume: 16, anno: 1996,
pagine: 309 - 314
SICI:
0250-8095(1996)16:4<309:SOSLIP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
UREMIA;
Keywords:
LIPASE; LIPOPROTEIN LIPASE; HEPATIC TRIGLYCERIDE LIPASE; HEMODIALYSIS; COAGULATION TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T. Shibasaki et al., "SIGNIFICANCE OF SERUM LIPASE IN PATIENTS UNDERGOING HEMODIALYSIS", American journal of nephrology, 16(4), 1996, pp. 309-314

Abstract

Serum levels of lipase (Lp) during the end of the dialysis showed a significant increase after the administration of heparin in hemodialysis patients. However, serum Lp levels were not increased after the administration of the anticoagulant nafamostat mesylate in hemodialysis patients. Serum levels of Lp were significantly correlated with serum levels of lipoprotein lipase (LPL), hepatic triglyceride lipase (H-TGL) and nonesterified fatty acid (NEFA) 20 min after the administration ofheparin during maintenance hemodialysis. Lp activity did not appear with the NEFA ligand for determining the NEFA activity. Inhibitors of LPL and H-TGL reduced the measured Lp activity in vitro. The main mechanism of elevated measured serum Lp activity in hemodialysis patients was determined to be cross-reactivity with LPL or H-TGL. Furthermore, measurement of Lp may be a method for determining optimal coagulation time in patients with hemodialysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:28:22