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Titolo:
INSULIN SENSITIVITY AND ATHEROSCLEROSIS
Autore:
HOWARD G; OLEARY DH; ZACCARO D; HAFFNER S; REWERS M; HAMMAN R; SELBY JV; SAAD MF; SAVAGE P; BERGMAN R;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,MED CTR BLVD WINSTON SALEM NC 27157 TUFTS NEW ENGLAND MED CTR,DEPT RADIOL BOSTON MA 00000 UNIV TEXAS,DIV CLIN EPIDEMIOL SAN ANTONIO TX 78285 UNIV COLORADO,HLTH SCI CTR,DEPT PREVENT MED & BIOMETR DENVER CO 80262 KAISER PERMANENTE,DIV RES OAKLAND CA 00000 UNIV SO CALIF,MED CTR,DEPT MED,DIV DIABET HYPERTENS & NUTR LOS ANGELES CA 00000 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 90033
Titolo Testata:
Circulation
fascicolo: 10, volume: 93, anno: 1996,
pagine: 1809 - 1817
SICI:
0009-7322(1996)93:10<1809:ISAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTIMA-MEDIA THICKNESS; MEXICAN-AMERICANS; CAROTID ATHEROSCLEROSIS; BLOOD-PRESSURE; RISK-FACTORS; RESISTANCE; BLACK; MEN; ARTERIES; GLUCOSE;
Keywords:
ATHEROSCLEROSIS; DIABETES MELLITUS; INSULIN; CAROTID ARTERIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
G. Howard et al., "INSULIN SENSITIVITY AND ATHEROSCLEROSIS", Circulation, 93(10), 1996, pp. 1809-1817

Abstract

Background Reduced insulin sensitivity has been proposed as an important risk factor in the development of atherosclerosis. However, insulin sensitivity is related to many other cardiovascular risk factors, including plasma insulin levels, and it is unclear whether an independent role of insulin sensitivity exists. Large epidemiological studies that measure insulin sensitivity directly have not been conducted. Methods and Results The Insulin Resistance Atherosclerosis Study (IRAS) evaluated insulin sensitivity (S-1) by the frequently sampled intravenousglucose tolerance test with analysis by the minimal model of Bergman. IRAS measured intimal-medial thickness (IMT) of the carotid artery asan index of atherosclerosis by use of noninvasive B-mode ultrasonography. These measures, as well as factors that may potentially confound or mediate the relationship between insulin sensitivity and atherosclerosis, were available in relation to 395 black, 457 Hispanic, and 542 non-Hispanic white IRAS participants. There was a significant negativeassociation between S, and the IMT of the carotid artery both in Hispanics and in non-Hispanic whites. This effect was reduced but not totally explained by adjustment for traditional cardiovascular disease risk factors, glucose tolerance, measures of adiposity, and fasting insulin levels. There was no association between S-1 and the IMT of the carotid artery in blacks. The association between S-1 and the IMT was stronger for the internal carotid artery than for the common carotid artery in all ethnic groups. Conclusions Higher levels of insulin sensitivity are associated with less atherosclerosis in Hispanics and non-Hispanic whites but not in blacks. This effect is partially mediated by traditional cardiovascular risk factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:15:14