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Titolo:
REGULATION OF G-PROTEIN FUNCTION - IMPLICATIONS FOR HEART-DISEASE
Autore:
MEIJ JTA;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT PHARMACOL DALLAS TX 75235
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 1-2, volume: 157, anno: 1996,
pagine: 31 - 38
SICI:
0300-8177(1996)157:1-2<31:ROGF-I>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; ALPHA; FAILURE;
Keywords:
G PROTEIN; ADENYLATE CYCLASE; PHOSPHOLIPASE C; GAP; HEART DISEASE; SIGNAL TRANSDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.T.A. Meij, "REGULATION OF G-PROTEIN FUNCTION - IMPLICATIONS FOR HEART-DISEASE", Molecular and cellular biochemistry, 157(1-2), 1996, pp. 31-38

Abstract

Heterotrimeric GTP-binding and -hydrolyzing proteins (G proteins) link members of a family of seven-helix transmembrane receptors (G protein-coupled receptors, GPCR) to intracellular effecters. The coupling mechanism involves the G protein completing a cycle of activation, dissociation into a and py subunits, deactivation, and reassociation. At the center of this cycle is the a subunit, in which activation by GPCR, GTPase activity, and regulation of effector are combined. Whereas Ga'sfunctional domains and residues had already been inferred from mutagenesis studies, the recent solution of the crystal structure has elucidated the structural basis of a subunit function. It is now clear that an irregularity in any GPCR pathway component could cause a physiological defect. This is confirmed by the identification of mutations in GPCR and Ga's in various human diseases. Although several cardiomyopathies are associated with abnormal GPCR function, mutations are unlikely in these disorders. The last few years, other aspects of G protein function have moved into focus: e.g. posttranslational modifications; effector regulation by py subunits; GTPase activating protein (GAP) activity of effecters; G protein expression levels etc. When comparing the regulation of G protein functional activity in cAMP and in inositol phosphate generating pathways, an extrapolation can be made to data on the status of these pathways in some cardiovascular diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:52:39