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Titolo:
THE ENDOCRINOLOGY OF THE MENOPAUSE
Autore:
BURGER HG;
Indirizzi:
PRINCE HENRYS INST MED RES,POB 5152 CLAYTON VIC 3168 AUSTRALIA
Titolo Testata:
Maturitas
fascicolo: 2, volume: 23, anno: 1996,
pagine: 129 - 136
SICI:
0378-5122(1996)23:2<129:TEOTM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; PITUITARY-OVARIAN FUNCTION; POSTMENOPAUSAL WOMEN; BINDING GLOBULIN; INHIBIN CONCENTRATIONS; LUTEINIZING-HORMONE; REPRODUCTIVE LIFE; POST-MENOPAUSE; GONADOTROPIN; TRANSITION;
Keywords:
ENDOCRINOLOGY; PITUITARY-OVARIAN AXIS; FOLLICLE STIMULATING HORMONE; MENOPAUSE; GONADOTROPIN; ESTROGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
H.G. Burger, "THE ENDOCRINOLOGY OF THE MENOPAUSE", Maturitas, 23(2), 1996, pp. 129-136

Abstract

Changes in the endocrinology of the pituitary-ovarian axis first become manifest al about the age of 40, a selective rise in serum folliclestimulating hormone (FSH) levels occurring al about the same time as a marked acceleration in the loss of primordial follicles from the ovary. FSK levels gradually increase with increasing age in women who continue to cycle regularly. During the menopausal transition, initialed when changes in cycle frequency or in menstrual flow are first observed, both gonadotrophins, oestradiol and inhibin show a marked degree ofvariability with abrupt changes from typical post-menopausal patternsto those characteristic of the reproductive age group. Within 1-2 years after the final menstrual period or menopause; FSH levels are markedly elevated, luteinizing hormone (LH) levels moderately so, while oestradiol and inhibin levels are low or undetectable. Post-menopausally,adrenal androstenedione is the major source of oestrogen and serum testosterone levels fall moderately, with oophorectomy leading to a further significant fall. Serum sex hormone binding globulin levels fall to a small degree post-menopausally. Areas of persisting controversy include the question of whether oestradiol levels fall with increasing age prior to the onset of the menopausal transition, the relative rolesof oestradiol and inhibin in the selective rise of serum FSH and the role of serum androgens post-menopausally.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:49:08