Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ADP-INDUCED P-SELECTIN EXPRESSION ON PLATELETS AS A PREDICTOR OF SUCCESSFUL THROMBOLYSIS
Autore:
YUSUF SW; SANDERSON H; HEPTINSTALL S; NURDEN AT; WENHAM PW; HOPKINSON BR;
Indirizzi:
UNIV NOTTINGHAM HOSP NOTTINGHAM NG7 2UH ENGLAND HOP CARDIOL,URA 1464 CNRS PESSAC FRANCE
Titolo Testata:
Blood coagulation & fibrinolysis
fascicolo: 2, volume: 7, anno: 1996,
pagine: 266 - 269
SICI:
0957-5235(1996)7:2<266:APEOPA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR; REOCCLUSION; REPERFUSION; ANTIBODY; ASPIRIN;
Keywords:
THROMBOLYSIS; P-SELECTIN; ADENOSINE DIPHOSPHATE; PLATELET ACTIVATION; FLOW CYTOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
S.W. Yusuf et al., "ADP-INDUCED P-SELECTIN EXPRESSION ON PLATELETS AS A PREDICTOR OF SUCCESSFUL THROMBOLYSIS", Blood coagulation & fibrinolysis, 7(2), 1996, pp. 266-269

Abstract

Unlike coronary thrombolysis, the role of platelet activity in the outcome of local thrombolytic therapy for peripheral ischaemia is not well understood In the present study ten patients undergoing local pulsespray thrombolysis (PST) with recombinant tissue-type plasminogen activator (rt-PA), six patients undergoing conventional infusion thrombolysis (CT) with rt-PA and another six patients undergoing arteriographywith iopamidol were studied Venous blood samples obtained before and after the procedure were analysed using a flow cytometric technique for detection of platelet activation after labelling platelets with VH10, a monoclonal antibody against P-selectin. In the present study no significant differences were observed in P-selectin expression before and after any of the procedures, except that P-selectin expression following ADP stimulation was reduced in patients who had received conventional thrombolysis. Unexpectedly, we observed relatively greater P-selectin expression, particularly after ADP stimulation, both before and following thrombolysis in ten patients in whom thrombolysis was successful compared with six patients in whom thrombolysis was unsuccessful. ADP-induced P-selectin expression on platelets may therefore be a useful predictor of outcome of peripheral intra-arterial thrombolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 08:52:28