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Titolo:
EFFECT OF ADRENOCORTICOTROPIN STIMULATION ON THE SYNTHESIS OF 19-NORALDOSTERONE IN MAN
Autore:
TAKEDA Y; MIYAMORI I; YONEDA T; FURUKAWA K; HATAKEYAMA H; INABA S; ITO Y; TAKEDA R; MABUCHI H;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2 KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT HLTH SCI KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 5, volume: 81, anno: 1996,
pagine: 1852 - 1855
SICI:
0021-972X(1996)81:5<1852:EOASOT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSTERONE-PRODUCING ADENOMA; SODIUM RESTRICTION; URINARY-EXCRETION; 18,19-DIHYDROXYCORTICOSTERONE; CELLS; 19-NOR-DEOXYCORTICOSTERONE; 19-NOR-ALDOSTERONE; 18-HYDROXY-19-NORCORTICOSTERONE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "EFFECT OF ADRENOCORTICOTROPIN STIMULATION ON THE SYNTHESIS OF 19-NORALDOSTERONE IN MAN", The Journal of clinical endocrinology and metabolism, 81(5), 1996, pp. 1852-1855

Abstract

The hormone, 19-noraldosterone, which was recently shown to be synthesized and produced in the human adrenal gland, exhibits potent mineralocorticoid and hypertensinogenic activities. This hormone is controlled in part by the renin-angiotensin system. We studied the effects of ACTH stimulation on the synthesis of 19-noraldosterone in vitro and in six normal men. 19-Noraldosterone was measured by a specific RIA afterthe urine extract or incubation medium was purified by high performance liquid chromatography. The 24-h urinary excretion of 19-noraldosterone increased approximately I-fold during the administration of ACTH (40 U, injected im twice daily for 3 days). Virtually identical responses were observed with aldosterone, 18-hydroxycorticosterone, 18,19-dihydroxycorticosterone, and 18-hydroxy-19-norcorticosterone. Glomerulosacells isolated from human adrenals were incubated with angiotensin II(10(-7), 10(-8), and 10(-9) mol/L) or ACTH (10(-8), 10(-9) and 10(-10) mol/L). Angiotensin II and ACTH increased the production of 19-noraldosterone dose-dependently from isolated glomerulosa cells. The secretion of aldosterone, 18-hydroxycorticosterone, 18, 19-dihydroxycorticosterone, and 18-hydroxy-19-norcorticosterone in response to angiotensinII and ACTH was identical to that of 19-noraldosterone. These observations suggest that 19-noraldosterone is stimulated by the renin-angiotensin system as well as ACTH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:18:22