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Titolo:
VASOPRESSIN RECEPTOR EXPRESSION AND MUTATION ANALYSIS IN CORTICOTROPIN-SECRETING TUMORS
Autore:
DAHIA PLM; AHMEDSHUAIB A; JACOBS RA; CHEW SL; HONEGGER J; FAHLBUSCH R; BESSER GM; GROSSMAN AB;
Indirizzi:
UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,DEPT ENDOCRINOL LONDON EC1A 7BE ENGLAND UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,DEPT ENDOCRINOL LONDON EC1A 7BE ENGLAND UNIV ERLANGEN NURNBERG,NEUROCHIRURG KLIN W-8520 ERLANGEN GERMANY
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 5, volume: 81, anno: 1996,
pagine: 1768 - 1771
SICI:
0021-972X(1996)81:5<1768:VREAMA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENTIAL-DIAGNOSIS; PITUITARY-ADENOMAS; CUSHINGS-SYNDROME; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P.L.M. Dahia et al., "VASOPRESSIN RECEPTOR EXPRESSION AND MUTATION ANALYSIS IN CORTICOTROPIN-SECRETING TUMORS", The Journal of clinical endocrinology and metabolism, 81(5), 1996, pp. 1768-1771

Abstract

Vasopressin is an important regulator of hypothalamo-pituitary-adrenal axis activation, primarily acting through the V3 receptor (V3R). Many patients with ACTH-secreting pituitary adenomas, but not normal individuals, respond to desmopressin, a relatively V2-specific vasopressinagonist, with increased ACTH and cortisol levels. We have searched for mutations of the V3R gene in ACTH-secreting pituitary adenomas and one ectopic ACTH-secreting tumor. No abnormalities were found in 12 tumors studied by PCR-single strand conformation polymorphism (PCR-SSCP) analysis. We then verified by RT-PCR whether the response to desmopressin was due to overexpression of the V3R or abnormal expression of theV2R in the pituitary tumor. We found that the V2R gene was expressed in a number of corticotroph tumors and in the ACTH-secreting ectopic tumor, and that the V3R gene appears to be overexpressed in these tumors. We conclude that V3R mutations are unlikely to be present in the ACTH-secreting tumors we examined, but that the V2R gene is expressed inthe majority of the samples tested, and the V3R is expressed in all of these tumors. We speculate that the response to the desmopressin test observed in patients with Gushing's disease may be due to abnormal expression of V3R or V2R in ACTH-secreting tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:15:21