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Titolo:
EXPRESSION OF HEME OXYGENASE-2 (HO-2)-LIKE IMMUNOREACTIVITY IN RAT-TISSUES
Autore:
GROZDANOVIC Z; GOSSRAU R;
Indirizzi:
FREE UNIV BERLIN,DEPT ANAT,KONIGIN LUISE STR 15 D-14195 BERLIN GERMANY FREE UNIV BERLIN,DEPT ANAT D-14195 BERLIN GERMANY
Titolo Testata:
Acta histochemica
fascicolo: 2, volume: 98, anno: 1996,
pagine: 203 - 214
SICI:
0065-1281(1996)98:2<203:EOHO(I>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CARBON-MONOXIDE; PLATELET-AGGREGATION; SMOOTH-MUSCLE; CYCLIC-GMP; INHIBITION; CELLS;
Keywords:
HEME OXYGENASE-2; RAT; FIBROCYTES; ENDOTHELIAL CELLS; SMOOTH MUSCLE CELLS; EPITHELIAL CELLS; GANGLION CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
Z. Grozdanovic e R. Gossrau, "EXPRESSION OF HEME OXYGENASE-2 (HO-2)-LIKE IMMUNOREACTIVITY IN RAT-TISSUES", Acta histochemica, 98(2), 1996, pp. 203-214

Abstract

Microsomal heme oxygenase (HO) is a cytochrome P-450-assisted oxidoreductase, which catalyzes the NADPH-dependent decomposition of heme to carbon monoxide (GO), biliverdin, and iron. Recent evidence suggests that CO, similar to nitric oxide (NO), may serve as gaseous biological signalling molecule, which acts by stimulating soluble guanylate cyclase in target cells. In the present investigation, we report the HO-like immunoreactivity (LIR) pattern of the constitutive HO isozyme, HO-2,and compare the results with recently published data on constitutive NO-producing nitric oxide synthase (NOS) in rat tissues. HO-2-LIR was most consistently observed in connective tissue elements (fibrocytes/-blasts and fibroblast-like cells, such as interstitial cells in the bowel), blood vessel wall constituents (arterial and venous endothelial cells, vascular smooth muscle cells), visceral smooth muscle cells (airway musculature, myometrium, muscularis mucosae of the small intestine), mesothelial cells of serous membranes and in select epithelial cell populations. HO-2-LIR was absent from the striated (skeletal and cardiac) musculature. HO-2 had a more widespread distribution and its expression largely differs from that of NOS. HO-2-LIR and NOS appear to be co-expressed in vascular endothelial cells and in selected nerve cell populations of certain parasympathetic and probably sensory ganglia. Our data suggest potential CO and NO systems as interrelated regulatory pathways in the local paracrine and autocrine control of diverse functional systems.

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Documento generato il 04/07/20 alle ore 05:28:41