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Titolo:
CEREBROSPINAL-FLUID SODIUM CONCENTRATION AND OSMOSENSITIVE SITES RELATED TO ARTERIAL-PRESSURE IN ANESTHETIZED RATS
Autore:
HIROSE M; NOSE H; CHEN M; YAWATA T;
Indirizzi:
SHINSHU UNIV,SCH MED,DEPT SPORTS MED,RES CTR AGING & ADAPTAT,3-1-1 ASAHI MATSUMOTO NAGANO 390 JAPAN SHINSHU UNIV,SCH MED,DEPT SPORTS MED,RES CTR AGING & ADAPTAT MATSUMOTO NAGANO 390 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT PHYSIOL,KAMIGYO KU KYOTO 602 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT ANAESTHESIOL,KAMIGYO KU KYOTO 602 JAPAN
Titolo Testata:
Pflugers Archiv
fascicolo: 6, volume: 431, anno: 1996,
pagine: 807 - 813
SICI:
0031-6768(1996)431:6<807:CSCAOS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; SUBFORNICAL ORGAN; SYMPATHETIC OUTFLOW; VASOPRESSIN RELEASE; HYPERTONIC NACL; ANGIOTENSIN-II; BLOOD-PRESSURE; NEURONS; THIRST; WATER;
Keywords:
OSMORECEPTORS; ARTERIAL PRESSURE REGULATION; CEREBROSPINAL FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Hirose et al., "CEREBROSPINAL-FLUID SODIUM CONCENTRATION AND OSMOSENSITIVE SITES RELATED TO ARTERIAL-PRESSURE IN ANESTHETIZED RATS", Pflugers Archiv, 431(6), 1996, pp. 807-813

Abstract

Intracerebroventricular injection of hypertonic saline induces experimental hypertension. To measure [Na] in the vicinity of osmosensitive sites, we continuously measured [Na] in cerebrospinal fluid ([Na](csf)) in the lateral ventricle (LV, n = 6), in the third ventricle (V3, n = 6) and in the medial preoptic nucleus (MPO, n = 6) ([Na](MPO)) with a Na-sensitive electrode together with mean arterial pressure (MAP) during infusion of hypertonic artificial cerebrospinal fluid (ACSF, [Na]= 1,000 meq/kg H2O) at 5 mu l/min for 3 min into the LV in urethane- anaesthetized rats. [Na](csf) in the LV began to increase at the beginning of infusion, reaching a peak of 48 +/- 9 meq/kg H2O (mean +/- SE)around the end of infusion, then recovering to the pre-infusion levelby 17 min. [Na](csf) in V3 changed similarly to that in the LV without any delay, although the peak value was reduced (61%, P < 0.05). In the MPO, in contrast the increase in [Na](MPO) was delayed (3 min, P < 0.002) and the peak reduced even further (to 37%, P < 0.01) compared with that in V3. Thereafter, it remained higher than the pre-infusion level until the end of recovery (P < 0.05). MAP began to increase at the onset of infusion (P < 0.05); the maximum increase of 16 +/- 2 mm Hg(n = 18) was reached at the end of infusion, whereafter this level was almost sustained until the end of the 22-min recovery period. To analyse quantitatively the relationship between MAP and [Na](csf), hypertonic ACSF was infused at 2.5 mu l/min into the LV. [Na](csf) in the LVand MAP increased at half the rates seen with 5 mu l/min. These results suggest that the first increase in MAP after hypertonic infusion into the LV is due to the increase in [Na] in the LV and V3, and that the subsequent sustained increase in MAP is related to the delayed increase in [Na] in the periventricular tissues of the V3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:02:10