Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ESTIMATING VARIANCE EFFECT OF QTL - AN IMPORTANT PROSPECT TO INCREASETHE RESOLUTION POWER OF INTERVAL MAPPING
Autore:
KOROL AB; RONIN YI; TADMOR Y; BARZUR A; KIRZHNER VM; NEVO E;
Indirizzi:
UNIV HAIFA,INST EVOLUT IL-31905 HAIFA ISRAEL ARO,NEVE YAAR RES CTR,CORN BREEDING UNIT IL-31900 HAIFA ISRAEL
Titolo Testata:
Genetical Research
fascicolo: 2, volume: 67, anno: 1996,
pagine: 187 - 194
SICI:
0016-6723(1996)67:2<187:EVEOQ->2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; MAXIMUM-LIKELIHOOD METHODS; MARKER LOCI; LINKAGE ANALYSIS; GENETIC-MARKERS; BACKCROSS; CROSSES; TOMATO; AID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Korol et al., "ESTIMATING VARIANCE EFFECT OF QTL - AN IMPORTANT PROSPECT TO INCREASETHE RESOLUTION POWER OF INTERVAL MAPPING", Genetical Research, 67(2), 1996, pp. 187-194

Abstract

Equal variances within quantitative trait locus (QTL) groups in the segregating population are a usual simplifying assumption in QTL mapping. The objective of this paper is to demonstrate the advantages of taking into account potential variance effect of QTLs within the framework of standard interval mapping approach. Using backcross case as an example, we show that the resolution power of the analysis may be increased in the presence of variance effect, if the latter is allowed for in the model. For a putative QTL (say, Ala) one can compare two situations, (i) sigma(Aa)(2) = sigma(aa)(2) = sigma(0)(2) and (ii) sigma(Aa)(2) not equal sigma(aa)(2). It was found that, if the variance effect of A/a is large enough, then in spite of the necessity to evaluate an increased number of parameters, the more correctly specified model provides an increase in the resolution power, as compared to the situation(i). This is not unexpected, if either sigma(Aa)(2) or sigma(aa)(2) in (ii) is lower than sigma(0)(2) from (i). But our conclusion holds even if sigma(Aa)(2) > sigma(aa)(2) = sigma(0)(2) or sigma(aa)(2) > sigma(Aa)(2) = sigma(0)(2). These advantages are illustrated on sweet corndata (F-3 families of F-2 genotypes). In particular, the log-likelihood test statistics and the parameter estimates obtained for a QT locusin the distal region of chromosome 2 show that the allele enhancing the trait is recessive over the opposite allele simultaneously for the mean value and variance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:49:18