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Titolo:
MRI-BASED SURFACE-AREA ESTIMATES IN THE NORMAL ADULT HUMAN BRAIN - EVIDENCE FOR STRUCTURAL ORGANIZATION
Autore:
SISODIYA S; FREE S; FISH D; SHORVON S;
Indirizzi:
NATL HOSP NEUROL & NEUROSURG,EPILEPSY RES GRP,QUEEN SQ LONDON WC1N 3BG ENGLAND
Titolo Testata:
Journal of Anatomy
, volume: 188, anno: 1996,
parte:, 2
pagine: 425 - 438
SICI:
0021-8782(1996)188:<425:MSEITN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORPUS-CALLOSUM; CORTICAL SURFACE; CEREBRAL-CORTEX; MODEL; MAMMALS; SIZE; NEOCORTEX; VOLUMES; NUMBER;
Keywords:
CEREBRAL CORTEX; VOLUMETRIC IMAGING; BRAIN MEASUREMENT; CORTICAL DYSGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S. Sisodiya et al., "MRI-BASED SURFACE-AREA ESTIMATES IN THE NORMAL ADULT HUMAN BRAIN - EVIDENCE FOR STRUCTURAL ORGANIZATION", Journal of Anatomy, 188, 1996, pp. 425-438

Abstract

There are a number of quantitative relationships between geometric parameters describing the structure of the normal human cerebral cortex examined in vivo using volumetric magnetic resonance imaging. A voxel-counting method is used to estimate grey-white interface surface area. The effects of bias associated with the method are considered. In 33 normal controls, the cerebral hemispheres were symmetric in terms of total volume, irrespective of handedness, but not in terms of surface areas for right-handers. The surface area of the grey matter-white matter interface was directly proportional to the cortical grey matter volume, suggesting that growth of the neocortex is primarily tangential, with repetition of a basic structural element rather than gross alterations in the thickness of the cortex. The majority of the surface areaof the grey-white interface lies within gyral white matter cores. Themean thickness of the cortex of the right cerebral hemisphere in vivowas 3.0 mm and that of the left 3.3 mm. There was a relationship between the cross-sectional area of the corpus callosum and grey-white interface surface area, suggesting that a fixed proportion of cortical neurons extend interhemispheric axons. These findings suggest that thereare general architectural principles governing the organisation of the complex, but ordered, human cerebral cortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:04:10