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Titolo:
GROWTH RESISTANCE-SIZED ARTERIES IN RESPONSE TO BLADDER HYPERTROPHY IN THE RAT - TIME-COURSE, DNA-SYNTHESIS AND LDH-ISOFORM PATTERN
Autore:
BOELS PJ; ARNER A; NILSSON BO; SVENSSON C; UVELIUS B;
Indirizzi:
LUND UNIV,DEPT PHYSIOL & NEUROSCI,SOLVEGATAN 19 S-22362 LUND SWEDEN LUND UNIV,DEPT PHYSIOL & NEUROSCI S-22362 LUND SWEDEN LUND UNIV,DEPT UROL S-22362 LUND SWEDEN
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 1, volume: 157, anno: 1996,
pagine: 93 - 99
SICI:
0001-6772(1996)157:1<93:GRAIRT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LACTATE-DEHYDROGENASE ACTIVITY; SMOOTH-MUSCLE; URINARY-BLADDER; FORCE;
Keywords:
LACTATE DEHYDROGENASE; SMOOTH MUSCLE; RESISTANCE VESSELS; HYPERTROPHY; GROWTH; [H-3] THYMIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Boels et al., "GROWTH RESISTANCE-SIZED ARTERIES IN RESPONSE TO BLADDER HYPERTROPHY IN THE RAT - TIME-COURSE, DNA-SYNTHESIS AND LDH-ISOFORM PATTERN", Acta Physiologica Scandinavica, 157(1), 1996, pp. 93-99

Abstract

Bladder growth was induced by partial urethral obstruction. Bladder hypertrophy was evident at 53 h after obstruction and continued over a 6 weeks period, Small bladder arteries were taken from fixed anatomical locations of the bladder circulation. mounted in a small vessel myograph and the optimal diameter for maximal isometric force development was determined (L(max), K+ = 125 mM stimulation). Bladder hypertrophy was associated with an enlarged L(max) from 53 h onward (compared withsham-operated controls) and L(max) continued to increase until 10 days after urethral obstruction. Between 10 days and 6 weeks no further increase of the diameter was observed. Increased diameters in vitro were accompanied by a transiently increased [H-3]Thymidine uptake in the small arteries which peaked al 53 h after obstruction but was still above background at 10 days. At this time point. small arterial growth was associated with a significant relative increase in the M isoform ofLDH as determined with agarose electrophoresis on tissue homogenates. Thus organ growth induced small vessel growth in the rat is characterized by a rapid onset, increased but transient DNA-turnover and LDH-isoform changes. The latter mimic changes seen in other types of smooth muscle growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:41:48