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Titolo:
LIPOPROTEIN(A) AND PERIPHERAL ATHEROSCLEROSIS IN OLDER ADULTS
Autore:
SUTTONTYRRELL K; EVANS RW; MEILAHN E; ALCORN HG;
Indirizzi:
UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT EPIDEMIOL,130 DESOTO ST PITTSBURGH PA 15261
Titolo Testata:
Atherosclerosis
fascicolo: 1, volume: 122, anno: 1996,
pagine: 11 - 19
SICI:
0021-9150(1996)122:1<11:LAPAIO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; MYOCARDIAL-INFARCTION; CEREBROVASCULAR-DISEASE; CAROTID ATHEROSCLEROSIS; LP(A) LIPOPROTEIN; RISK FACTOR; CHOLESTEROL; STENOSIS; PLASMA; APOLIPOPROTEIN)A>;
Keywords:
LIPOPROTEIN(A); ATHEROSCLEROSIS; PERIPHERAL VASCULAR DISEASE; CAROTID STENOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
K. Suttontyrrell et al., "LIPOPROTEIN(A) AND PERIPHERAL ATHEROSCLEROSIS IN OLDER ADULTS", Atherosclerosis, 122(1), 1996, pp. 11-19

Abstract

As part of an ancillary study to the Systolic Hypertension in the Elderly Program, carotid and lower extremity arterial disease (LEAD) wereevaluated in 369 subjects, 186 with a systolic blood pressure (SBP) greater than or equal to 160 mmHg, and 183 with SBP < 160 mmHg. Both groups had a diastolic blood pressure (DBP) < 90 mmHg. Internal carotid stenosis was identified by Doppler and LEAD was assessed using the ankle to arm systolic blood pressure ratio, commonly called the ankle/armindex (AAI). Lp(a) values were obtained from frozen sera and values greater than or equal to 20 mg/dl were considered elevated. Rates of carotid stenosis were 24% among those with an Lp(a) greater than or equal to 20 mg/dl and 14% among those with an Lp(a) level < 20 mg/dl (P = 0.020). The relationship between Lp(a) and LEAD was even stronger. Those with an Lp(a) greater than or equal to 20 mg/dl had a 36% prevalence of a low AAI vs 14% among those with a Lp(a) level < 20 mg/dl (P < 0.001). Lp(a) values were also associated with the severity of LEAD. Controlling for other risk factors did not reduce the association between either LEAD or carotid stenosis and an Lp(a) greater than or equal to 20 mg/dl. Thus, Lp(a) appears to be independently associated with peripheral atherosclerosis in older adults, both men and women. The relationship is particularly strong for atherosclerotic disease of the lower extremities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:41:47