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Titolo:
PROCAINE AND TIMING OF AORTIC DECLAMPING AFFECT VENTRICULAR REPERFUSION FIBRILLATION
Autore:
MUSTONEN PK; HIPPELAINEN MJ; POYHONEN MJ; REHNBERG LS;
Indirizzi:
KUOPIO UNIV HOSP,DEPT SURG,POB 1777 FIN-70211 KUOPIO FINLAND
Titolo Testata:
Annales chirurgiae et gynaecologiae
fascicolo: 1, volume: 85, anno: 1996,
pagine: 52 - 57
SICI:
0355-9521(1996)85:1<52:PATOAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD CARDIOPLEGIA; MYOCARDIAL PRESERVATION; LIDOCAINE; BYPASS; SURGERY; ARREST; TRIAL; TIME;
Keywords:
CORONARY BYPASS GRAFTING; AORTIC CROSS-CLAMPING AND DECLAMPING; CENTRAL ANASTOMOSIS; CARDIOPLEGIA; PROCAINE HYDROCHLORIDE; POSTISCHEMIC REPERFUSION; VENTRICULAR FIBRILLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P.K. Mustonen et al., "PROCAINE AND TIMING OF AORTIC DECLAMPING AFFECT VENTRICULAR REPERFUSION FIBRILLATION", Annales chirurgiae et gynaecologiae, 85(1), 1996, pp. 52-57

Abstract

Both ventricular fibrillation and electric defibrillation are detrimental to the myocardium. Therefore, we studied the effect of procaine hydrochloride during crystalloid cardioplegia and the effect of performing ail central anastomoses before aortic declamping in an attempt to prevent ventricular reperfusion fibrillation during coronary bypass operations. Seventy-four patients were randomised, first to receive procaine hydrochloride or saline during cardioplegia, and secondly, to have central anastomoses performed before or after aortic declamping. In patients receiving procaine in cardioplegic solution (n = 37), the mean ventricular fibrillation time was shorter (27 +/- 79 sec. vs 205 +/-161 sec., P < 0.0001), the proportion of patients spontaneously achieving stable rhythm was higher (67.6 % vs 13.5 %, P < 0.0001) and the mean number of defibrillations was lower (0.3 +/- 0.7 vs 2.4 +/- 1.7, P< 0.0001) than in patients receiving placebo (n = 37). Although the aortic occlusion time was longer (112 +/- 28 min vs 91 +/- 26 min, P = 0.0015) in patients with central anastomoses made during cardiac arrest (n = 35) and the mean fibrillation time Tvas shorter (53 +/- 87 sec.vs 173 +/- 179 sec., P = 0.0006) than compared with patients with central anastomoses made after declamping the aorta (n = 39), the mean number of defibrillations (1.2 +/- 1.7 vs 1.4 +/- 1.7, P = 0.59) and thecardiopulmonary bypass time (138 +/- 29 min vs 132 +/- 34 min, P = 0.47) were not statistically different between these groups. There were no differences in arrhythmias, conduction defects or postoperative recovery between the study groups. We conclude that both procaine hydrochloride during cardioplegia and the performance of central anastomoses of vein grafts during aortic occlusion effectively reduce reperfusion ventricular fibrillation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 11:58:32