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Titolo:
CYTOKINE PRODUCTION PATHWAY IN THE ELDERLY
Autore:
CARUSO C; CANDORE G; CIGNA D; DILORENZO G; SIRECI G; DIELI F; SALERNO A;
Indirizzi:
UNIV PALERMO,INST PATOL GEN I-90134 PALERMO ITALY UNIV PALERMO,INST MED INTERNA & GERIATRIA I-90134 PALERMO ITALY
Titolo Testata:
Immunologic research
fascicolo: 1, volume: 15, anno: 1996,
pagine: 84 - 90
SICI:
0257-277X(1996)15:1<84:CPPITE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTOCOMPATIBILITY COMPLEX REGULATION; MESSENGER-RNA EXPRESSION; CELL PRECURSOR FREQUENCY; AGE-RELATED-CHANGES; INTERLEUKIN-2 RECEPTOR; T-CELLS; THYMOPENTIN MODULATION; LYMPHOKINE PRODUCTION; IMMUNE-RESPONSE; DEFECT INVITRO;
Keywords:
AGING; AUTOIMMUNITY; CYTOKINES; IMMUNE RESPONSE; IMMUNODEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
C. Caruso et al., "CYTOKINE PRODUCTION PATHWAY IN THE ELDERLY", Immunologic research, 15(1), 1996, pp. 84-90

Abstract

It is well known that aging is associated with various alterations inlymphoid cell functions, particularly with a progressive decline in immune responsiveness to exogenous antigens and increasing incidence ofautoimmune phenomena. Many studies have been focused on the mechanisms of the immunologic features of aging. This review describes our results of studies performed to determine the influence of age on the capacity to produce interleukin-2 (IL-2), interferon-gamma (IFN-gamma), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-6 (IL-6) and tumor necrosis factor (TNF). Mitogen-stimulated cultures of mononuclear cells (MNC) from human beings were assessed for cytokine-producing capacity. A significant decrease in IFN-gamma and IL-2 production by MNC cultures from elderly individuals was observed. No significant difference was instead observed between cultures from elderly individuals and those from young ones as regards TNF-alpha, IL-4 and IL-6 production. Mitogen or antigen-stimulated cultures of MNC from aged mice also displayed a significant decrease in IFN-gamma and IL-2 production as well as TNF-beta. Instead IL-4 and IL-5 production significantly increased in these cultures. We suggest that this imbalanced cytokine productionmay well account for the pattern of immune response which may be observed in the elderly, i.e. a normal or increased humoral response (including autoimmune responses) in face of a low T cell immune responsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:05:27