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Titolo:
CHRONIC AUTOIMMUNE HEPATITIS FOLLOWING CH OLESTATIC HEPATITIS INDUCEDBY DROXICAM
Autore:
PEREZAGUILAR F; BERENGUER M; RAMIREZPALANCA JJ; PAYA A; VERASEMPERE FJ; SANCHEZCUENCA JM; BERENGUER J;
Indirizzi:
AVE CAMPANAR 21 E-46009 VALENCIA SPAIN HOSP LA FE,SERV MED DIGEST E-46009 VALENCIA SPAIN HOSP LA FE,SERV ANAT PATOL E-46009 VALENCIA SPAIN HOSP LA FE,UNIDAD INMUNOL EXPTL E-46009 VALENCIA SPAIN
Titolo Testata:
Medicina Clinica
fascicolo: 12, volume: 106, anno: 1996,
pagine: 460 - 462
SICI:
0025-7753(1996)106:12<460:CAHFCO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
SPA
Soggetto:
CHRONIC ACTIVE HEPATITIS; SUBMASSIVE NECROSIS; TOXIC HEPATITIS; LIVER-DISEASE; PIROXICAM; PHARMACOKINETICS; HEPATOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
F. Perezaguilar et al., "CHRONIC AUTOIMMUNE HEPATITIS FOLLOWING CH OLESTATIC HEPATITIS INDUCEDBY DROXICAM", Medicina Clinica, 106(12), 1996, pp. 460-462

Abstract

Droxicam in a nonsteroid antiinflammatory from the oxicam family which acts as a pro-drug, being transformed into pyroxicam after being hydrolized in the stomach and has induced several cases of cholestatic ormixed hepatitis. A clinical observation in which droxicam provoked initial cholestatic hepatitis which later developed into chronic autoimmune hepatitis is presented. It has been postulated that, after causingcholestatic hepatitis by hypersensitivity and within the context of aprevious autoimmune entity such as vitiligo, this drug triggered a silent autoimmune liver disease which was demonstrated clinical, analytical and histopathological manifestations 18 months later and required permanent immunosuppressive treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:11:50