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Titolo:
ABNORMALLY SHORT SERUM HALF-LIVES OF IGG IN BETA-2-MICROGLOBULIN-DEFICIENT MICE
Autore:
GHETIE V; HUBBARD JG; KIM JK; TSEN MF; LEE YF; WARD ES;
Indirizzi:
UNIV TEXAS,SW MED CTR,CTR CANC IMMUNOBIOL,5323 HARRY HINES BLVD DALLAS TX 75235 UNIV TEXAS,SW MED CTR,CTR CANC IMMUNOBIOL DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT MICROBIOL DALLAS TX 75235
Titolo Testata:
European Journal of Immunology
fascicolo: 3, volume: 26, anno: 1996,
pagine: 690 - 696
SICI:
0014-2980(1996)26:3<690:ASSHOI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-RECEPTOR; DEFICIENT MICE; T-CELLS; MHC; EXPRESSION; RAT; ANTIBODIES; REGION;
Keywords:
IGG CATABOLISM; FCRN; BETA-2-MICROGLOBULIN-DEFICIENT MICE; RECOMBINANT FC-HINGE FRAGMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
V. Ghetie et al., "ABNORMALLY SHORT SERUM HALF-LIVES OF IGG IN BETA-2-MICROGLOBULIN-DEFICIENT MICE", European Journal of Immunology, 26(3), 1996, pp. 690-696

Abstract

The MHC class I-related receptor, FcRn, mediates the transfer of maternal gamma globulin (IgG) to young rodents, primarily via intestinal transcytosis, and this provides humoral immunity for the first few weeks after birth. In a previous study, the site of mouse IgG1 (mIgG1) with which FcRn interacts has been mapped using recombinant wild-type andmutated Fc-hinge fragments. The site encompasses residues at the CH2-CH3 domain interface of Fc (Ile253, His310, Gln311, His433 and Asn434)and the same amino acids are involved in regulating the pharmacokinetics of the Fc-hinge fragments. This suggests that in addition to its known function, FcRn might also play a role in IgG homeostasis. Consistent with this hypothesis, in this study, we demonstrate that FcRn alpha-chain mRNA is present not only in neonatal brush border but also in other tissues of adult animals (liver, lung, spleen and endothelial cells). In addition, analysis of the pharmacokinetics of mouse Ig/Fc-hinge fragments in genetically manipulated mice that are deficient in theexpression of FcRn demonstrates that the beta-phase half-lives are abnormally short. These findings suggest that FcRn is involved in lgG homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:14:12