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Titolo:
NUCLEAR EXPORT OF LATE HIV-1 MESSENGER-RNAS OCCURS VIA A CELLULAR PROTEIN EXPORT PATHWAY
Autore:
FRIDELL RA; BOGERD HP; CULLEN BR;
Indirizzi:
DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,BOX 3025 DURHAM NC 27710 DUKE UNIV,MED CTR,HOWARD HUGHES MED INST DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT GENET DURHAM NC 27710
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 9, volume: 93, anno: 1996,
pagine: 4421 - 4424
SICI:
0027-8424(1996)93:9<4421:NEOLHM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-1 REV; GENE-EXPRESSION REQUIRES; VIRAL MESSENGER-RNA; TRANS-ACTIVATOR; TARGET SEQUENCE; BINDING-SITE; I REX; IMMUNODEFICIENCY; MOTIF; DEFINITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Fridell et al., "NUCLEAR EXPORT OF LATE HIV-1 MESSENGER-RNAS OCCURS VIA A CELLULAR PROTEIN EXPORT PATHWAY", Proceedings of the National Academy of Sciences of the United Statesof America, 93(9), 1996, pp. 4421-4424

Abstract

The Rev protein of HIV-1 is essential for the nuclear export of incompletely spliced viral mRNAs. This action depends on the mutationally defined Rev activation domain, which both binds the nucleoporin-like human cellular cofactor Rab/hRIP and also functions as a nuclear export signal. Protein kinase inhibitor alpha (PKI) also contains a potent nuclear export signal. However, PKI plays no role in nuclear RNA export and instead induces the nuclear export of a specific protein target, the catalytic subunit of cAMP-dependent protein kinase. Here, it is demonstrated that the nuclear export signal of PKI not only binds the Rab/hRIP cofactor specifically but also can effectively substitute for the Rev activation domain in mediating the nuclear export of HIV-I mRNAs. We conclude that HIV-1 Rev and PKI act through an identical nuclear export pathway and that Rev, rather than using a dedicated RNA export pathway, is instead acting as an adaptor that allows viral mRNAs to access a cellular protein export pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:53:56