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Titolo:
BLOOD RADICALS - REACTIVE NITROGEN SPECIES, REACTIVE OXYGEN SPECIES, TRANSITION-METAL IONS, AND THE VASCULAR SYSTEM
Autore:
DARLEYUSMAR V; HALLIWELL B;
Indirizzi:
UNIV LONDON KINGS COLL,PHARMACOL GRP,NEURODEGENERAT DIS RES CTR,MANRESA RD LONDON SW3 6LX ENGLAND UNIV LONDON KINGS COLL,PHARMACOL GRP,NEURODEGENERAT DIS RES CTR LONDON SW3 6LX ENGLAND UNIV BIRMINGHAM,DIV MOLEC & CELLULAR PATHOL,DEPT PATHOL BIRMINGHAM AL35294
Titolo Testata:
Pharmaceutical research
fascicolo: 5, volume: 13, anno: 1996,
pagine: 649 - 662
SICI:
0724-8741(1996)13:5<649:BR-RNS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; HUMAN-ENDOTHELIAL-CELLS; HUMAN ATHEROSCLEROTIC LESIONS; HYDROGEN-PEROXIDE ALTERS; SMOOTH-MUSCLE CELLS; NITRIC-OXIDE; LIPID-PEROXIDATION; OXIDATIVE MODIFICATION; SUPEROXIDE PRODUCTION; SCAVENGER RECEPTOR;
Keywords:
OXYGEN RADICAL; NITRIC OXIDE; PEROXYNITRITE; OXIDATIVE STRESS; VASCULAR SYSTEM; REACTIVE NITROGEN SPECIES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
194
Recensione:
Indirizzi per estratti:
Citazione:
V. Darleyusmar e B. Halliwell, "BLOOD RADICALS - REACTIVE NITROGEN SPECIES, REACTIVE OXYGEN SPECIES, TRANSITION-METAL IONS, AND THE VASCULAR SYSTEM", Pharmaceutical research, 13(5), 1996, pp. 649-662

Abstract

Free radicals, such as superoxide, hydroxyl and nitric oxide, and other ''reactive species'', such as hydrogen peroxide, hypochlorous acid and peroxynitrite, are formed in vivo. Some of these molecules, e.g. superoxide and nitric oxide, can be physiologically useful, but they can also cause damage under certain circumstances. Excess production of reactive oxygen or nitrogen species (ROS, RNS), their production in inappropriate relative amounts (especially superoxide and NO.) or deficiencies in antioxidant defences may result in pathological stress to cells and tissues. This oxidative stress can have multiple effects. It can induce defence systems, and render tissues more resistant to subsequent insult. If oxidative stress is excessive or if defence and repairresponses are inadequate, cell injury can be caused by such mechanisms as oxidative damage to essential proteins, lipid peroxidation, DNA strand breakage and base modification, and rises in the concentration of intracellular ''free'' Ca2+. Considerable evidence supports the viewthat oxidative damage involving both ROS and RNS is an important contributor to the development of atherosclerosis. Peroxynitrite (derived by reaction of superoxide with nitric oxide) and transition metal ions(perhaps released by injury to the vessel wall) may contribute to lipid peroxidation in atherosclerotic lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:21:40