Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DOSE-RESPONSE EFFECT OF IN-VIVO ADMINISTRATION OF ENDOTOXIN ON POLYMORPHONUCLEAR LEUKOCYTES OXIDATIVE BURST
Autore:
KAJDACSYBALLA A; DOI EM; LERNER MR; BALES WD; ARCHER LT; WUNDER PR; WILSON MF; BRACKETT DJ;
Indirizzi:
MED COLL WISCONSIN,DEPT PATHOL,W WISCONSIN AVE MILWAUKEE WI 53226 UNIV OKLAHOMA,HLTH SCI CTR,DEPT PATHOL OKLAHOMA CITY OK 73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT SURG OKLAHOMA CITY OK 73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT MED OKLAHOMA CITY OK 73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT ANESTHESIOL OKLAHOMA CITY OK 73190 VET AFFAIRS MED CTR OKLAHOMA CITY OK 73190
Titolo Testata:
Shock
fascicolo: 5, volume: 5, anno: 1996,
pagine: 357 - 361
SICI:
1073-2322(1996)5:5<357:DEOIAO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-NEUTROPHILS; BACTERIAL LIPOPOLYSACCHARIDE; RESPIRATORY BURST; PRODUCT FORMATION; ACTIVATION; STIMULATION; INJURY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A. Kajdacsyballa et al., "DOSE-RESPONSE EFFECT OF IN-VIVO ADMINISTRATION OF ENDOTOXIN ON POLYMORPHONUCLEAR LEUKOCYTES OXIDATIVE BURST", Shock, 5(5), 1996, pp. 357-361

Abstract

In vitro, endotoxin primes polymorphonuclear leukocytes (PMNs) to respond with a greater oxidative burst. The purpose of the present study was to investigate the in vivo effect of a wide range of single endotoxin bolus doses using a rat model. PMNs were subsequently challenged in vitro with phorbol ester to produce reactive oxygen intermediates (ROI). Flow cytometric determination of ROI production by PMNs using thedichlorofluorescin conversion assay showed that although low doses induced priming, large doses induced a decrease in ROI production by thefew PMNs that remained in the circulation. By 6 h after injection, ROI production had returned to basal levels after a high dose, and was still increasing after a low dose. Neutropenia occurred immediately after endotoxin injection. After 6 h, PMN counts returned to almost normal levels with a high dose, but rebound neutrophilia occurred with a small dose. In contrast to in vitro studies, in vivo injection showed a response pattern that varied widely with dose and time of observation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:56:47