Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ISOLATED AXILLARY RECURRENCES AFTER CONSERVATIVE TREATMENT OF BREAST-CANCER
Autore:
RENOLLEAU C; MERVIEL P; CLOUGH KB; ASSELAIN B; CAMPANA F; DURAND JC;
Indirizzi:
INST CURIE,SECT MED & HOSPITALIERE,SERV CHIRURG GEN,26 RUE ULM F-75231 PARIS FRANCE INST CURIE,SECT MED & HOSPITALIERE,SERV CHIRURG GEN F-75231 PARIS FRANCE INST CURIE,SECT MED & HOSPITALIERE,SERV BIOSTAT F-75231 PARIS FRANCE INST CURIE,SECT MED & HOSPITALIERE,SERV RADIOTHERAPIE F-75231 PARIS FRANCE
Titolo Testata:
European journal of cancer
fascicolo: 4, volume: 32A, anno: 1996,
pagine: 617 - 621
SICI:
0959-8049(1996)32A:4<617:IARACT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSTITUT-GUSTAVE-ROUSSY; RADIOTHERAPY; DISSECTION; CARCINOMA; EXPERIENCE; EXCISION; SURGERY;
Keywords:
BREAST CANCER; CONSERVATIVE TREATMENT; AXILLARY RECURRENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
C. Renolleau et al., "ISOLATED AXILLARY RECURRENCES AFTER CONSERVATIVE TREATMENT OF BREAST-CANCER", European journal of cancer, 32A(4), 1996, pp. 617-621

Abstract

This retrospective study presents the diagnostic, prognostic and therapeutic problems raised by axillary recurrences (AR). 1589 cases of breast cancer measuring less than 3 cm, treated at the Institut Curie between 1981 and 1987, were studied by a combination of surgery and radiotherapy. Treatment of the breast always included wide local excision associated with irradiation. The axilla was treated either by dissection (865 cases) or by irradiation (724 cases) and 159 patients receivedchemotherapy. 26 patients (2%) developed AR, confirmed by fine needleaspiration cytology in 92% of cases. None of these 26 patients had initially received chemotherapy. The treatment of the AR was variable, adapted to the initial treatment. 22 patients retained their breast during treatment of the AR and none subsequently developed a local recurrence. 4 mastectomies were performed and histological examination revealed a subclinical local recurrence in 2 cases. The TNM classification,menopausal status, size of the tumour and hormonal receptor status were not risk factors for AR. Young age (P = 0.01) and high histologicalgrade (P = 0.03) were Significant risk factors for AR. The AR rate was similar whether axillary dissection or axillary irradiation had beenperformed. The overall 5-year survival after initial treatment was 85% for AR and 95% for the reference population. The overall 4-year survival after recurrence was 69% and the incidence of metastasis was markedly increased (P = 0.002). 2 of the 26 patients developed lymphoedemaof the arm after treatment of AR. We confirm that AR worsens the prognosis, but not significantly more than local recurrence. Young age andthe modified histological grading of Scarff Bloom and Richardson wererisk factors for AR. Although excision of the AR is necessary to ensure local control, mastectomy is unnecessary when clinical examination and mammography are normal. (C) 1996 Elsevier Science Ltd

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 08:58:23