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Titolo:
EFFECTS OF WILLFUL VENTILATORY CONTROL ON RESPIRATORY SENSATION DURING HYPERCAPNIA
Autore:
OKU Y; SAIDEL GM; CHERNIACK NS; ALTOSE MD;
Indirizzi:
KYOTO UNIV,CHEST DIS RES INST,DEPT CLIN PHYSIOL KYOTO 606 JAPAN CASE WESTERN RESERVE UNIV,DEPT MED CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT BIOMED ENGN CLEVELAND OH 44106 CLEVELAND VA MED CTR CLEVELAND OH 00000
Titolo Testata:
Respiration
fascicolo: 3, volume: 63, anno: 1996,
pagine: 137 - 143
SICI:
0025-7931(1996)63:3<137:EOWVCO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREATHLESSNESS; EXERCISE; DYSPNEA; SLEEP;
Keywords:
HYPERCAPNIA; DYSPNEA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
Y. Oku et al., "EFFECTS OF WILLFUL VENTILATORY CONTROL ON RESPIRATORY SENSATION DURING HYPERCAPNIA", Respiration, 63(3), 1996, pp. 137-143

Abstract

Remarkable augmentation of breathing discomfort has been noted when ventilation is constrained to the steady state level during progressivehypercapnia. However, the effect of willful enhancement of ventilation on breathing discomfort remains to be evaluated. The present study examined the effects of moderate willful increases or decreases in ventilation during progressive hypercapnia on breathing discomfort in 12 subjects. There were a total of 5 rebreathing trials. In the first (F1)and the fifth trials the subjects rebreathed freely. In the other trials subjects breathed by tracking a target to achieve hypercapnic ventilatory responses that were the same (HCVR-S), 25% higher (HCVR-H) and25% lower (HCVR-L) than in the Fl trial. Breathing discomfort was assessed every 30 s by a 150-mm visual analog scale (VAS). The sensational response (dVAS/dPCO(2)) during HCVR-S [3.8 +/- (SE) 0.8 mm/Torr] wassignificantly smaller (p < 0.01) than that during the Fl (6.3 +/- 0.8mm/ Torr) trial. HCVR-H resulted in a further decrease in dVAS/dPCO(2) to 3.1 +/- 0.7 mm/Torr as compared to HCVR-S (p < 0.05). HCVR-L significantly increased dVAS/dPCO(2) to 4.9 +/- 0.7 mm/Torr compared to HCVR-S (p < 0.05). The final free rebreathing ventilatory response was significantly larger than the initial free rebreathing response (2.7 +/- 0.5 as compared to 2.1 +/- 0.4 liters/min/Torr, p < 0.01). However, the sensational response did not change(6.3 +/- 0.8 vs. 5.8 +/- 0.7 mm/Torr). These rebreathing studies indicate that willful control of respiration decreases respiratory sensation even at comparable levels of ventilation. In particular, moderate willful increases in ventilation produce an ameliorating effect on the sensation of breathing discomfort.

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Documento generato il 22/01/20 alle ore 21:47:40