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Titolo:
EPIDEMIOLOGY OF BRAIN LYMPHOMA AMONG PEOPLE WITH OR WITHOUT ACQUIRED-IMMUNODEFICIENCY-SYNDROME
Autore:
COTE TR; MANNS A; HARDY CR; YELLIN FJ; HARTGE P; LEMP G; WEST D; SINGLETON J; YOUNG J; KERNDT P; DEAPEN D; GINZBERG M; ANTONCULVER H; LIEB S; HOPKINS R; WILLIAMS B; LIFF J; MORGAN D; PARKIN W;
Indirizzi:
NIH,EXECUT PLAZA N,RM 434 BETHESDA MD 20892 NCI,DIV CANC ETIOL,VIRAL EPIDEMIOL SECT BETHESDA MD 00000 NCI,DIV CANC ETIOL,ENVIRONM EPIDEMIOL BRANCH BETHESDA MD 00000 ATLANCTIC RES CORP ROCKVILLE MD 00000
Titolo Testata:
Journal of the National Cancer Institute
fascicolo: 10, volume: 88, anno: 1996,
pagine: 675 - 679
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T.R. Cote et al., "EPIDEMIOLOGY OF BRAIN LYMPHOMA AMONG PEOPLE WITH OR WITHOUT ACQUIRED-IMMUNODEFICIENCY-SYNDROME", Journal of the National Cancer Institute, 88(10), 1996, pp. 675-679

Abstract

Background: In recent years, brain lymphoma incidence has dramatically increased, presumably because of elevated risk of brain lymphoma among persons with acquired immunodeficiency syndrome (AIDS), Purpose: The objective of this study was to estimate independent incidence and survival rates of brain lymphoma among persons with or without AIDS and to understand the epidemiologic features of this cancer, Methods: We linked AIDS and cancer registry reports at nine state and local health departments and compared the demographics, histology, and survival of brain lymphoma cases among persons with or without AIDS, The data werelimited to people under 70 years of age, We calculated the incidence of brain lymphoma among persons with AIDS and compared observed cases with those expected, The differences were statistically analyzed usingthe Poisson test, Epidemiologic features of brain lymphoma in personswith or without AIDS were compared using the chi-squared test, the Student's t test, and the chi-squared test for linear trend, The logranktest was used to compare survival rates estimated by the Kaplan-Meiertechnique, All P values were two-sided, Results: We matched 50 989 AIDS registry reports to 859 398 cancer registry reports (data from 1981to 1990) and found 431 people with both AIDS and brain lymphoma, Among people with AIDS, those developing brain lymphoma versus those without brain lymphoma were more likely to be white (70% versus 59%; P < .001) and had homosexuality as their only human immunodeficiency virus risk factor (75% versus 64%; P < .001), Of the 431 patients, 223 developed brain lymphomas during 47 465 person-years of observation after diagnosis of AIDS, The absolute incidence rate of brain lymphoma among persons with AIDS was 4.7/1000 person-years (95% confidence interval = 4.1-5.3/1000 person-years), 3600-fold higher than the base-line rate in the general population, From 1980 through 1989, overall counts of brain lymphoma increased ninefold, Most of this increase was derived from persons with AIDS, but a substantial increase also occurred among persons without AIDS (0.04/100 000 in 1982 to 0.28/100 000 in 1989) (chi-squared test for trend; P < .05). The median survival was shortest for persons with AIDS and brain lymphoma (2 months), was intermediate for persons with brain lymphoma without AIDS (5-7 months), and was longest for persons with AIDS without brain lymphoma (14 months) (P < .05 for all comparisons), Conclusions: This analysis distinguishes the separate epidemiologies of brain lymphoma incidence among persons with or without AIDS and shows brain lymphoma incidence among persons with AIDS to be several thousand-fold higher than that in the general population, The study documents the overwhelming effect of AIDS-associated brain lymphoma on the overall rate in the general population and demonstrates a significantly rising trend, although of a lesser magnitude, among persons without AIDS, Implications: This study emphasizes a greaterneed to bring health care resources to this burgeoning epidemic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:51:23