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Titolo:
EXPRESSION OF BETA(2)-MICROGLOBULIN-FREE HLA CLASS-I ALPHA-CHAINS ON ACTIVATED T-CELLS REQUIRES INTERNALIZATION OF HLA CLASS-I HETERODIMERS
Autore:
PICKL WF; HOLTER W; STOCKL J; MAJDIC O; KNAPP W;
Indirizzi:
UNIV VIENNA,INST IMMUNOL,BORSCHKEGASSE 8A A-1090 VIENNA AUSTRIA
Titolo Testata:
Immunology
fascicolo: 1, volume: 88, anno: 1996,
pagine: 104 - 109
SICI:
0019-2805(1996)88:1<104:EOBHCA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-MEDIATED ENDOCYTOSIS; COMPLEX CLASS-I; COATED PIT FORMATION; HEAVY-CHAINS; INTRACELLULAR POTASSIUM; MONOCLONAL-ANTIBODIES; TRANSFERRIN RECEPTOR; MOLECULES; PEPTIDE; BETA-2-MICROGLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
W.F. Pickl et al., "EXPRESSION OF BETA(2)-MICROGLOBULIN-FREE HLA CLASS-I ALPHA-CHAINS ON ACTIVATED T-CELLS REQUIRES INTERNALIZATION OF HLA CLASS-I HETERODIMERS", Immunology, 88(1), 1996, pp. 104-109

Abstract

HLA class I molecules on activated T cells are expressed as heterodimers associated with beta(2)-microglobulin (beta(2)-m) and also beta(2)-m-free HLA class I alpha-chains. Mechanisms leading to the expressionof the activation associated beta(2)-m-free HLA class I alpha-chains are poorly defined, however. Upon enzymatical removal of HLA class I alpha-chains on activated T cells, re-expression is observed within minutes upon reculture, reaching half-maximal levels within 1 hr. This process is independent of de novo protein synthesis and of export of newly synthesized proteins. Inhibition of the formation of coated pits bypotassium depletion of cells abrogated the re-expression of HLA classI alpha-chains, suggesting that recycling events of HLA class I heterodimers via endosomal compartments are required for the generation of monoclonal antibody LA45-reactive a-chains. Furthermore, the rate of alpha-chain generation seems to be governed by the amount of cell surface-expressed HLA class I heterodimers. Taken together these findings suggest that beta(2)-m-free HLA class I alpha-chains are generated during the process of class I heterodimer recycling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:14:01