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Titolo:
ROLE OF INTERLEUKIN-2 AND INTERFERON-GAMMA IN INDUCING PRODUCTION OF IGG SUBCLASSES IN LYMPHOCYTES OF HUMAN NEWBORNS
Autore:
KAWANO Y; NOMA T;
Indirizzi:
EBINA GEN HOSP,DEPT PEDIAT,1320 KAWARAGUCHI EBINA KANAGAWA 24304 JAPAN SAITAMA MED SCH,DEPT PEDIAT SAITAMA JAPAN
Titolo Testata:
Immunology
fascicolo: 1, volume: 88, anno: 1996,
pagine: 40 - 48
SICI:
0019-2805(1996)88:1<40:ROIAII>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELL DIFFERENTIATION; HUMAN CORD BLOOD; POKEWEED MITOGEN; T-CELLS; IMMUNOGLOBULIN PRODUCTION; STAPHYLOCOCCUS-AUREUS; HUMAN-ANTIBODIES; INVITRO; ACTIVATION; ONTOGENY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
Y. Kawano e T. Noma, "ROLE OF INTERLEUKIN-2 AND INTERFERON-GAMMA IN INDUCING PRODUCTION OF IGG SUBCLASSES IN LYMPHOCYTES OF HUMAN NEWBORNS", Immunology, 88(1), 1996, pp. 40-48

Abstract

Unlike lymphocytes from adults, lymphocytes from cord blood of neonates cannot synthesize immunoglobulin G (IgG) in response to pokeweed mitogen (PWM). By using this mitogen in concert with interferon-gamma (IFN-gamma), interleukin-2 (IL-2), or interleukin-6 (IL-6), we studied the induction of IgG subclass molecules in lymphocytes of human neonates. IFN-gamma induced a limited, but substantial, enhancement of IgG2 production by neonatal lymphocytes. IL-2 dose dependently increased theproduction of each neonatal IgG subclass, whereas IL-6 did not. However, in adult lymphocytes, and under specific conditions, IL-6 or IL-2 each increased the production of all four IgG subclasses. Early in theculture IFN-gamma synergized with IL-2 during the latter or whole culture period to enhance cord blood IgG2 levels. This finding contrastedwith the adult IgG2 synthesis synergistically up-regulated by IFN-gamma and IL-6, IL-2 caused a graded increase in immunoglobulin production in neonatal lymphocytes with IgG3 being the highest and IgG2 the lowest, thus corresponding to the differential increase of serum levels of IgG3/IgG1 and IgG4/IgG2 early in childhood. Results suggest that IL-2, but not IL-6, is critical to the development of human IgG subclass production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:43:19