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Titolo:
ROLE OF THE DORSOMEDIAL HYPOTHALAMUS IN THE CARDIOVASCULAR-RESPONSE TO STRESS
Autore:
DIMICCO JA; STOTZPOTTER EH; MONROE AJ; MORIN SM;
Indirizzi:
INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,635 BARNHILL DR INDIANAPOLIS IN 46202
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 2, volume: 23, anno: 1996,
pagine: 171 - 176
SICI:
0305-1870(1996)23:2<171:ROTDHI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; POSTERIOR HYPOTHALAMUS; PARAVENTRICULAR NUCLEUS; INDUCED TACHYCARDIA; HEART-RATE; ANESTHETIZED RATS; GABA ANTAGONISTS; DEFENSE REACTION; CONSCIOUS RATS; CELL-BODIES;
Keywords:
BLOOD PRESSURE; DORSOMEDIAL HYPOTHALAMUS; GABA; GLUTAMATE; HEART RATE; MICROINJECTION; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; STRESS; SYMPATHETIC NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Dimicco et al., "ROLE OF THE DORSOMEDIAL HYPOTHALAMUS IN THE CARDIOVASCULAR-RESPONSE TO STRESS", Clinical and experimental pharmacology and physiology, 23(2), 1996, pp. 171-176

Abstract

1. Disinhibition of the dorsomedial hypothalamus (DMH) in rats by local microinjection of GABA(A) receptor antagonists evokes behavioural and physiological changes resembling those seen in acute experimental stress. 2. Conversely, similar microinjection of muscimol, a potent agonist at inhibitory GABA(A) receptors, virtually abolishes stress-induced increases in heart rate and arterial pressure. 3. Blockade of excitatory amino acid (EAA) receptors in the DMH also attentuates stress-induced cardiovascular changes and microinjection of kainate, AMPA or NMDA at low doses elicits cardiovascular effects resembling those seen in stress. Paradoxically, injection of higher doses of NMDA or of glutamate into this region has no consistent effect. 4. The cardiovascular effects of bicuculline methiodide, a GABA(A) receptor antagonist, as well as those of NMDA and/or kainate were assessed after identical injection into either the DMH, the paraventricular nucleus (PVN) or the area between the two nuclei in both anaesthetized and conscious rats. For each agent, a similar pattern was seen, with the largest increases in heart rate and arterial pressure occurring after injection into the DMH and the smallest changes resulting from injection into the PVN. 5. In a parallel study, bilateral microinjection of muscimol into the DMH dramatically reduced air stress-induced cardiovascular changes; similar injection into the area of the PVN had no effect, while injection into the area between the nuclei produced an intermediate effect. 6. Our findings suggest that activation of neurons in the region of the DMH mediates stress-induced cardiovascular changes and that the activityof these neurons may be determined by the balance of tone at inhibitory GABA(A) receptors and EAA receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 09:02:13