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Titolo:
GENETICALLY-ENGINEERED RESISTANCE TO DENGUE-2 VIRUS TRANSMISSION IN MOSQUITOS
Autore:
OLSON KE; HIGGS S; GAINES PJ; POWERS AM; DAVIS BS; KAMRUD KI; CARLSON JO; BLAIR CD; BEATY BJ;
Indirizzi:
COLORADO STATE UNIV,DEPT MICROBIOL,ARTHROPAD BARNE & INFECT DIS LAB FT COLLINS CO 80523
Titolo Testata:
Science
fascicolo: 5263, volume: 272, anno: 1996,
pagine: 884 - 886
SICI:
0036-8075(1996)272:5263<884:GRTDVT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID SEQUENCE; YELLOW-FEVER VIRUS; NUCLEOTIDE-SEQUENCE; MONOCLONAL-ANTIBODIES; JAMAICA GENOTYPE; TYPE-2 VIRUS; PROTEINS; EXPRESSION; GENOME; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
K.E. Olson et al., "GENETICALLY-ENGINEERED RESISTANCE TO DENGUE-2 VIRUS TRANSMISSION IN MOSQUITOS", Science, 272(5263), 1996, pp. 884-886

Abstract

The control of arthropod-borne virus diseases such as dengue may ultimately require the genetic manipulation of mosquito vectors to disruptvirus transmission to human populations. To reduce the ability of mosquitoes to transmit dengue viruses, a recombinant Sindbis virus was used to transduce female Aedes aegypti with a 567-base antisense RNA targeted to the premembrane coding region of dengue type 2 (DEN-2) virus. The transduced mosquitoes were unable to support replication of DEN-Pvirus in their salivary glands and therefore were not able to transmit the virus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:15:16