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Titolo:
CRYSTAL-STRUCTURE OF THE YEAST TFIIA TBP/DNA COMPLEX/
Autore:
GEIGER JH; HAHN S; LEE S; SIGLER PB;
Indirizzi:
YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,POB 6666 NEW HAVEN CT 06510 YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM NEW HAVEN CT 06510 YALE UNIV,HOWARD HUGHES MED INST NEW HAVEN CT 06510 FRED HUTCHINSON CANC RES CTR SEATTLE WA 98104
Titolo Testata:
Science
fascicolo: 5263, volume: 272, anno: 1996,
pagine: 830 - 836
SICI:
0036-8075(1996)272:5263<830:COTYTT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION INITIATION SITES; SACCHAROMYCES-CEREVISIAE; FACTOR-IIA; TFIIA; SUBUNITS; ACTIVATION; CDNA; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Geiger et al., "CRYSTAL-STRUCTURE OF THE YEAST TFIIA TBP/DNA COMPLEX/", Science, 272(5263), 1996, pp. 830-836

Abstract

The crystal structure of the yeast TFIIA/TBP/TATA promoter complex was solved to 3 angstrom resolution by double-edge multiple wavelength anomalous diffraction from two different species of anomalous scattering elements in the same crystal. The large and small subunits of TFIIA associate intimately to form both domains of a two-domain folding pattern. TFIIA binds as a heterodimer to the side of the TBP/TATA complex opposite to the side that binds TFIIB and does not alter the TBP/DNA interaction. The six-stranded beta-sandwich domain interacts with the amino-terminal end of TBP through a stereospecific parallel beta-strandinterface and with the backbone of the TATA box and the 5'-flanking B-DNA segment. The four-helix-bundle domain projects away from the TBP/TATA complex, thereby presenting a substantial surface for further protein-protein interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 21:19:00