Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MITOCHONDRIAL GENES AS SITES OF PRIMARY ACTION OF STEROID-HORMONES
Autore:
DEMONACOS CV; KARAYANNI N; HATZOGLOU E; TSIRIYIOTIS C; SPANDIDOS DA; SEKERIS CE;
Indirizzi:
NATL HELLEN RES FDN,INST BIOL RES & BIOTECHNOL,VASSILEOS CONSTANTINOUAVE 48 GR-11635 ATHENS GREECE NATL HELLEN RES FDN,INST BIOL RES & BIOTECHNOL GR-11635 ATHENS GREECE UNIV CRETE,SCH MED,DEPT MOLEC VIROL IRAKLION GREECE UNIV ATHENS,SCH MED,DEPT BIOL CHEM GR-11527 ATHENS GREECE
Titolo Testata:
Steroids
fascicolo: 4, volume: 61, anno: 1996,
pagine: 226 - 232
SICI:
0039-128X(1996)61:4<226:MGASOP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C-OXIDASE; DEXAMETHASONE TREATMENT; DNA-SEQUENCE; TRANSCRIPTION; STIMULATION; ELEMENTS; INVITRO;
Keywords:
HORMONE; THYROID; RECEPTOR; MITOCHONDRIA; REGULATION; TRANSCRIPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
C.V. Demonacos et al., "MITOCHONDRIAL GENES AS SITES OF PRIMARY ACTION OF STEROID-HORMONES", Steroids, 61(4), 1996, pp. 226-232

Abstract

Steroid and thyroid hormones act on nuclear gene transcription by activating protein receptors, which in rum bind to hormone response elements (HREs). Among the cell-specific processes regulated by steroid receptors is energy metabolism through increased synthesis of respiratoryenzymes. As some of these enzymes are encoded by both nuclear and mitochondrial genes, coordination of their synthesis is probable, inter alia at the transcriptional level. We have postulated a direct effect of steroid hormones on mitochondrial gene transcription and here present the following evidence in support of this hypothesis. 1) The human and rodent mitochondrial genomes contain nucleotide sequences similar both to type I and type II HREs. 2) Glucocorticoid receptors (GR) rapidly translocate from the cytoplasm into mitochondria after administration of glucocorticoids. This process has been reproduced in vitro and deletion of the N-terminal part of the glucocorticoid receptor stops translocation into mitochondria. 3) Gel shift analysis has demonstrated binding of GR to putative mitochondrial GR elements. 4) In transfection experiments, mitochondrial HREs confer dexamethasone inducibility onhybrid reporter constructs, abolished in the presence of excess RU38486. 5) Similar results were obtained for thyroid hormone receptor (TR(alpha)) localization, import, and binding to TR elements. These findings, taken with the demonstrated effects of steroid (and thyroid) hormones on mitochondrial transcription and respiratory enzyme biosynthesis, strongly support the hypothesis of a direct effect of steroid (and thyroid) hormones on mitochondrial gene transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:01:54