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Titolo:
MODULATION OF NEISSERIA PORIN (PORB) BY CYTOSOLIC ATP GTP OF TARGET-CELLS - PARALLELS BETWEEN PATHOGEN ACCOMMODATION AND MITOCHONDRIAL ENDOSYMBIOSIS/
Autore:
RUDEL T; SCHMID A; BENZ R; KOLB HA; LANG F; MEYER TF;
Indirizzi:
MAX PLANCK INST BIOL,INFEKT BIOL ABT,SPEMANNSTR 34 D-72076 TUBINGEN GERMANY MAX PLANCK INST BIOL,INFEKT BIOL ABT D-72076 TUBINGEN GERMANY MAX PLANCK INST INFEKT BIOL,MOLEK BIOL ABT D-10117 BERLIN GERMANY UNIV WURZBURG,THEODOR BOVERI INST BIOZENTRUM,LEHRSTUHL BIOTECHNOL D-97074 WURZBURG GERMANY UNIV TUBINGEN,INST PHYSIOL 1 D-72076 TUBINGEN GERMANY
Titolo Testata:
Cell
fascicolo: 3, volume: 85, anno: 1996,
pagine: 391 - 402
SICI:
0092-8674(1996)85:3<391:MONP(B>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER-MEMBRANE PROTEINS; DEPENDENT ANION CHANNEL; HUMAN EPITHELIAL-CELLS; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; LIPID BILAYERS; GONOCOCCAL-INFECTION; SELECTIVE CHANNELS; RECEPTOR PROTEIN; BACTERIAL PORIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
T. Rudel et al., "MODULATION OF NEISSERIA PORIN (PORB) BY CYTOSOLIC ATP GTP OF TARGET-CELLS - PARALLELS BETWEEN PATHOGEN ACCOMMODATION AND MITOCHONDRIAL ENDOSYMBIOSIS/", Cell, 85(3), 1996, pp. 391-402

Abstract

PorB of the pathogenic Neisseria species belongs to the large family of pore-forming proteins (porins) produced by gram-negative bacteria. PorB is exceptional in that it is capable of translocating vectoriallyinto membranes of infected target cells and functions in the infection process. Here we report on an unexpected similarity between Neisserial PorB and mitochondrial porins. Both porin classes interact with purine nucleoside triphosphates, which down-regulate pore size and cause a shift in voltage dependence and ion selectivity. Patch-clamp analyses indicate that PorB channel activity is tightly regulated in intact epithelial cells. In light of recent findings on the pivotal role of PorB in virulence and the prevention of phagosome lysosome fusion, thesedata provide important mechanistic clues on the intracellular pathogen accommodation reminiscent of mitochondrial endosymbiosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:25:16