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Titolo:
SFA-2, A NOVEL BZIP TRANSCRIPTION FACTOR-INDUCED BY HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I, IS HIGHLY EXPRESSED IN MATURE LYMPHOCYTES
Autore:
HASEGAWA H; UTSUNOMIYA Y; KISHIMOTO K; TANGE Y; YASUKAWA M; FUJITA S;
Indirizzi:
EHIME UNIV,SCH MED,DEPT INTERNAL MED 1 SHIGENOBU EHIME 79102 JAPAN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 222, anno: 1996,
pagine: 164 - 170
SICI:
0006-291X(1996)222:1<164:SANBTF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENHANCER BINDING-PROTEIN; KAPPA-B P50; HTLV-I; DNA-BINDING; TRANSACTIVATOR TAX; TRANS-ACTIVATION; GENE-EXPRESSION; PROMOTER; INTERLEUKIN-2; P40X;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
H. Hasegawa et al., "SFA-2, A NOVEL BZIP TRANSCRIPTION FACTOR-INDUCED BY HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I, IS HIGHLY EXPRESSED IN MATURE LYMPHOCYTES", Biochemical and biophysical research communications, 222(1), 1996, pp. 164-170

Abstract

A novel cellular gene, SFA-2, was isolated by differential hybridization of a cDNA library, using probes obtained from an adult T-cell leukemia cell line in comparison with normal CD4(+) T cells and MOLT-4 cell line. The mRNA of the SFA-2 gene is approximately 0.9-kb in size andencodes a protein of 125 amino acids, containing a basic region-leucine zipper DNA-binding domain. The N-terminal region of SFA-2 is rich in serine and contains a consensus sequence for casein kinase II phosphorylation. The SFA-2 gene was strongly expressed in mature T and B lymphocytes, and was up-regulated after transformation by human T-cell leukemia virus type I. The SFA-2 did not homodimerize efficiently but formed heterodimer preferentially with c-Jun. The SFA-2/c-Jun heterodimer bound preferentially to the AP-1 and CRE sites. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:55:25