Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BOTH REDUCTIVE FORMS OF 17-BETA-HYDROXYSTEROID DEHYDROGENASE (TYPE-1 AND TYPE-3) ARE EXPRESSED DURING DEVELOPMENT IN THE MOUSE TESTIS
Autore:
SHA J; BAKER P; OSHAUGHNESSY PJ;
Indirizzi:
UNIV GLASGOW,DEPT VET PHYSIOL,VET REPROD RES GRP,BEARSDEN RD GLASGOW G61 1QH LANARK SCOTLAND
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 222, anno: 1996,
pagine: 90 - 94
SICI:
0006-291X(1996)222:1<90:BRFO1D>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEXUAL-DIFFERENTIATION; TESTICULAR DESCENT; RAT; CELLS; FETAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J. Sha et al., "BOTH REDUCTIVE FORMS OF 17-BETA-HYDROXYSTEROID DEHYDROGENASE (TYPE-1 AND TYPE-3) ARE EXPRESSED DURING DEVELOPMENT IN THE MOUSE TESTIS", Biochemical and biophysical research communications, 222(1), 1996, pp. 90-94

Abstract

Androstenedione is reduced to form testosterone by 17-beta-hydroxysteriod dehydrogenase (17 beta HSD) and two different reductive isoforms of the enzyme have been identified (types 1 and 3). In this study, levels of mRNA encoding both reductive isoforms have been measured duringfetal and post-natal development in the mouse. In fetal and neonatal testes mRNA encoding both type 1 and type 3 isoforms was present at relatively high levels reaching a peak at postnatal day 5. Thereafter, mRNA levels of both 17 beta HSD isoforms fell to low levels until day 30 when there was a marked increase in the levels of the type 3 isoform. The presence of the type 117 beta HSD enzyme in fetal testes may explain the virilization of the mesonephric (Wolffian) duct which occurs in pseudohermaphrodite individuals lacking the type 3 isoform. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:41:43