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Titolo:
INFLAMMATORY BOWEL-DISEASE IN C.B-17 SCID MICE RECONSTITUTED WITH THECD45RB(HIGH) SUBSET OF CD4(-CELLS() T)
Autore:
LEACH MW; BEAN AGD; MAUZE S; COFFMAN RL; POWRIE F;
Indirizzi:
SCHERING PLOUGH CORP,RES INST,POB 32,ROUTE 94 S LAFAYETTE NJ 07848 DNAX RES INST MOLEC & CELLULAR BIOL INC PALO ALTO CA 94304
Titolo Testata:
The American journal of pathology
fascicolo: 5, volume: 148, anno: 1996,
pagine: 1503 - 1515
SICI:
0002-9440(1996)148:5<1503:IBICSM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LAMINA PROPRIA LYMPHOCYTES; HUMAN INTESTINAL-MUCOSA; VERSUS-HOST DISEASE; ULCERATIVE-COLITIS; CROHNS-DISEASE; MONOCLONAL-ANTIBODY; MONONUCLEAR-CELLS; INTERFERON-GAMMA; ACTIVATION; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
M.W. Leach et al., "INFLAMMATORY BOWEL-DISEASE IN C.B-17 SCID MICE RECONSTITUTED WITH THECD45RB(HIGH) SUBSET OF CD4(-CELLS() T)", The American journal of pathology, 148(5), 1996, pp. 1503-1515

Abstract

Chronic inflammation developed spontaneously in the large intestine of C.B-17 sicd mice restored with the CD45RB(high) subset of CD4(+) T cells obtained from normal BALB/c mice. The inflammation, which extended diffusely from the cecum to the rectum, was localized to the lamina propria of mildly affected mice but became transmural in severely affected mice. Immunohistochemical and flow cytometric analyses showed that the inflammatory infiltrate contained numerous macrophages accompanied by moderate numbers of activated CD4(+) lymphocytes. Some mice alsohad scattered multinucleated giant cells. Mucin depletion and epithelial hyperplasia resulting in glandular elongation and mucosal thickening were also consistently seen. Less frequent findings included ulceration with fibrosis, crypt abscesses, crypt loss, adn granulomatous inflammation. Immunofluorescent analysis of inflamed large intestinal sections demonstrated increased epithelial expression of major histocompatibility class II antigens. The changes in the large intestine of these mice are similar to those seen in patients with idiopathic inflammatory bowel disease (Crohn's disease and ulcerative colitis). This murine model may be useful for studying mucosal immunoregulation as it relates to the pathogenesis and treatment of chronic inflammatory bowel diseases in the large intestine of human patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 04:54:43