Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXPRESSION OF E-CADHERIN IN PRIMARY AND METASTATIC PROSTATE-CANCER
Autore:
CHENG L; NAGABHUSHAN M; PRETLOW TP; AMINI SB; PRETLOW TG;
Indirizzi:
CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,INST PATHOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,MED CTR,DEPT EPIDEMIOL & BIOSTAT CLEVELAND OH 44106
Titolo Testata:
The American journal of pathology
fascicolo: 5, volume: 148, anno: 1996,
pagine: 1375 - 1380
SICI:
0002-9440(1996)148:5<1375:EOEIPA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEP-SECTION TECHNIQUE; MOLECULE E-CADHERIN; CARCINOMA; DIFFERENTIATION; GRADE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
L. Cheng et al., "EXPRESSION OF E-CADHERIN IN PRIMARY AND METASTATIC PROSTATE-CANCER", The American journal of pathology, 148(5), 1996, pp. 1375-1380

Abstract

Immunohistochemical studies have suggested that E-cadherin may be a useful prognostic marker in prostate cancer Previous studies have depended oil cryostat sections of tissues selected grossly, Many prostate cancers, even when extensive, are not visible grossly many others cannot be demarcated sharply grossly, The wide applicability of prognostic markers after total prostatectomy will depend upon methods that can beapplied to tissue selected based upon the histopathological examination of the entire prostate Our purpose was to investigate the possibility that E-cadherin could be demonstrated in paraffin-embedded whole prostates and metastatic prostate cancer: Microwaving in citrate buffer tons the best of five methods tested for the demonstration of E-cadherin in paraffin-embedded prostate and was used to investigate 53 primary prostate cancers from 44 patients and lymph node metastases front 14patients Metastases of prostate cancer to lymph nodes expressed less (P = 0.008) E-cadherin than primary prostate cancers, The expression of E-cadherin correlated with the histopathological differentiation (Gleason grade) of primary prostate cancers (P = 0.03, P-trend = 0.003). The use of monoclonal anti-human E-cadherin (HECD-1) with microwaving in citrate buffer followed by immunoperoxidase staining with heavy metal enhancement for the demonstration of E-cadherin in paraffin-embedded tissue will, for the fil st time, allow the use of archival tissue for prognostic studies of E-cadherin in prostate cancer and other tissue, Our results are consistent with the hypothesis that aggressive prostate cancers exhibit decreased expression of E-cadherin and demonstrate the feasibility of long-term prognostic studies of this molecule in the usually, multiple prostate cancers found in whole, formalin-fixed,paraffin-embedded resected prostates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 07:35:20