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Titolo:
BEN AS A PRESUMPTIVE TARGET RECOGNITION MOLECULE DURING THE DEVELOPMENT OF THE OLIVOCEREBELLAR SYSTEM
Autore:
CHEDOTAL A; POURQUIE O; EZAN F; SANCLEMENTE H; SOTELO C;
Indirizzi:
HOP LA PITIE SALPETRIERE,INSERM U106,BATIMENT PEDIAT,47 BLVD HOP F-75651 PARIS 13 FRANCE HOP LA PITIE SALPETRIERE,INSERM U106 F-75651 PARIS 13 FRANCE COLL FRANCE,CNRS,INST EMBRYOL CELLULAIRE & MOLEC F-94736 NOGENT SUR MARNE FRANCE
Titolo Testata:
The Journal of neuroscience
fascicolo: 10, volume: 16, anno: 1996,
pagine: 3296 - 3310
SICI:
0270-6474(1996)16:10<3296:BAAPTR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHICK NERVOUS-SYSTEM; ADHESION MOLECULES; AVIAN CEREBELLUM; INFERIOR OLIVE; IMMUNOGLOBULIN SUPERFAMILY; GALLUS-DOMESTICUS; PURKINJE-CELLS; RAT-BRAIN; EXPRESSION; SURFACE;
Keywords:
INFERIOR OLIVE; PURKINJE CELL; CLIMBING FIBER; CHICK; CELL ADHESION; PROJECTION MAP FORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
A. Chedotal et al., "BEN AS A PRESUMPTIVE TARGET RECOGNITION MOLECULE DURING THE DEVELOPMENT OF THE OLIVOCEREBELLAR SYSTEM", The Journal of neuroscience, 16(10), 1996, pp. 3296-3310

Abstract

It has been shown previously that in the chick embryo the cell adhesion molecule BEN/SC1/DM-GRASP is expressed by neurons in the inferior olive (IO) and by their terminal axonal arbors in the cerebellar cortex, the climbing fibers (Pourquie et al., 1992b), Here, new information on the expression of BEN during the formation of the olivocerebellar projection adds the important notion that BEN is also expressed by the cerebellar targets of inferior olivary axons, Purkinje cells (PCs) anddeep nuclear neurons. This expression is transient, starting at E7-E8and vanishing shortly after hatching. More importantly, BEN expression is restricted to precise subsets of IO neurons and PCs. In the cerebellar cortex, BEN-immunoreactive (BEN-IR) structures are not found randomly but are distributed according to a reproducible pattern of parasagittal stripes. A maximum of four distinct sagittal stripes is found in each lobule, along the whole rostrocaudal extent of the cerebellum. Moreover, BEN-expressing stripes belong to two classes; one contains BEN-IR climbing fibers terminating on BEN-IR PCs and the other, more frequent class is solely composed of BEN-IR climbing fibers. Organotypic cultures of isolated cerebella have shown that the expression of BENin the IO and in the cerebellum arise independently, probably becauseof an intrinsic developmental program. Thus, the cell adhesion molecule BEN meets all criteria for a recognition molecule involved in the formation of the olivocerebellar projection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:44:50