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Titolo:
MODULATION OF SEXUAL-BEHAVIOR IN THE RAT BY A POTENT AND SELECTIVE ALPHA(2)-ADRENOCEPTOR ANTAGONIST, DELEQUAMINE (RS-15385-197)
Autore:
TALLENTIRE D; MCRAE G; SPEDDING M; CLARK R; VICKERY B;
Indirizzi:
INST RECH SERVIER,CROISSY RES CTR,125 CHEMIN RONDE F-78290 CROISSY SUR SEINE FRANCE SYNTEX INC,RES PALO ALTO CA 94304 SYNTEX RES CTR EDINBURGH EH14 4AP MIDLOTHIAN SCOTLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 1, volume: 118, anno: 1996,
pagine: 63 - 72
SICI:
0007-1188(1996)118:1<63:MOSITR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT RECEPTOR AGONIST; YOHIMBINE; 8-OH-DPAT; IMPOTENCE; TRIAL;
Keywords:
DELEQUAMINE; YOHIMBINE; ALPHA-ADRENOCEPTORS; SEXUAL BEHAVIOR IN RAT; IMPOTENCE; 5-HT1A RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
D. Tallentire et al., "MODULATION OF SEXUAL-BEHAVIOR IN THE RAT BY A POTENT AND SELECTIVE ALPHA(2)-ADRENOCEPTOR ANTAGONIST, DELEQUAMINE (RS-15385-197)", British Journal of Pharmacology, 118(1), 1996, pp. 63-72

Abstract

1 The contributions of alpha(2)-adrenoceptors and 5-HT1A receptors tosexual behaviour in the rat have been re-evaluated by use of a highlypotent and selective alpha(2)-adrenoceptor antagonist, delequamine (RS-15385197), yohimbine, idazoxan and the partial agonist at 5-HT1A receptors, 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT). 2 In a model where naive male rats were introduced to oestrogen-progesterone primed, sexually receptive female rats, delequamine (0.4-6.4 mg kg(-1), p.o.) dose-relatedly increased the sexual behaviour score over the entire dose-range whereas yohimbine was effective at only one dose, 2 mg kg(-1), p.o.. Idazoxan was active only at 2.5 and 5 mg kg(-1), p.o. Yohimbine, but neither delequamine nor idazoxan, decreased ejaculation latency. 8-OH-DPAT (0.1 and 0.25 mg kg(-1), s.c.) reduced the time, and the number of intromissions to ejaculation without affecting other parameters. A combination of delequamine (0.4 mg kg(-1), p.o.) and 8-OH-DPAT (0.1 mg kg(-1) s.c.) increased the percentage of rats mounting, intromitting and ejaculating, and reduced ejaculation latency and the number of intromissions. 3 In orchidectomized, sexually experienced rats exposed to sexually receptive females, delequamine, idazoxan and yohimbine increased the number of rats mounting, and there was a tendency to increase the number of animals intromitting, but no effect on ejaculatory behaviour. 4 In ovariectomized female rats brought to low level receptivity by priming with low dose injections of oestradiol benzoateand progesterone, delequamine, at 1.6 and 6.4 mg kg(-1) p.o., increased lordosis, while yohimbine, at 2, 4 and 8 mg kg(-1) p.o., reduced lordotic responses to sexually experienced males in a dose-dependent manner. 8-OH-DPAT at 0.1, 0.25 mg kg(-1), s.c. reduced lordosis in a dose-dependent manner. 5 These findings may be explained on the basis thatyohimbine is an alpha(2)-adrenoceptor antagonist with affinity for 5-HT1A receptors and that the effects of 5-HT1A receptors may modulate the sexual behaviour responses to alpha(2)-receptor antagonism in some models. Thus, in contrast to yohimbine, the highly-selective alpha(2)-adrenoceptor antagonist, delequamine, was very effective in increasingthe behavioural score in male and female rats over a wide dose-range.

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Documento generato il 02/04/20 alle ore 19:52:29