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Titolo:
HIGH-DOSE THERAPY FOLLOWED BY AUTOLOGOUS HEMATOPOIETIC STEM-CELL INFUSION FOR PATIENTS WITH MULTIPLE-MYELOMA
Autore:
BENSINGER WI; ROWLEY SD; DEMIRER T; LILLEBY K; SCHIFFMAN K; CLIFT RA; APPELBAUM FR; FEFER A; BARNETT T; STORB R; CHAUNCEY T; MAZIARZ RT; KLARNET J; MCSWEENEY P; HOLMBERG L; MALONEY DG; WEAVER CH; BUCKNER CD;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,1124 COLUMBIA ST,M185 SEATTLE WA 98104 UNIV WASHINGTON,SCH MED SEATTLE WA 98195 SEATTLE VET AFFAIRS HOSP SEATTLE WA 00000 SWEDISH MED CTR,MED CTR,TUMOR INST SEATTLE WA 00000 PUGET SOUND ONCOL CONSORTIUM SEATTLE WA 00000 OREGON HLTH SCI MED CTR PORTLAND OR 00000
Titolo Testata:
Journal of clinical oncology
fascicolo: 5, volume: 14, anno: 1996,
pagine: 1447 - 1456
SICI:
0732-183X(1996)14:5<1447:HTFBAH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; COMBINATION CHEMOTHERAPY; MONOCLONAL-ANTIBODY; CYCLOPHOSPHAMIDE; MELPHALAN; BUSULFAN; MALIGNANCY; SURVIVAL; LYMPHOMA; REGIMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
W.I. Bensinger et al., "HIGH-DOSE THERAPY FOLLOWED BY AUTOLOGOUS HEMATOPOIETIC STEM-CELL INFUSION FOR PATIENTS WITH MULTIPLE-MYELOMA", Journal of clinical oncology, 14(5), 1996, pp. 1447-1456

Abstract

Purpose: To evaluate the outcome of patients with multiple myeloma (MM) who received high-dose therapy followed by autologous bone marrow (BM) or peripheral-blood stem-cell (PBSC) infusion. Patients and Methods: Sixty-three consecutive patients with MM received autologous BM (n = 13) or PBSC with or without BM (n = 50) following regimens that contained busulfan (Bu) and cyclophosphamide (Cy) (n = 18), modified total-body irradiation (TBI) followed by Bu and Cy (n = 36), or Bu, melphalan, and thiotepa (n = 9). Two thirds of the patients had resistant disease and 69% had received more than 6 months of previous chemotherapy. Results cmd Conclusion: Recovery of peripheral-blood cell counts was more rapid in patients who received PBSC more with or without BM than in patients who received BM alone. Sixteen of 63 patients (25%) died of complications of treatment within 100 days. Nineteen (40%) of 48 assessable patients achieved a complete response (CR), 23 (48%) had a partial response (PR), and six (12%) had no response. The probabilities of survival and survival without relapse or progression for all 63 patients at 3.0 years were .43 and .21, respectively. The probability of relapse or progression at 3 years was .69, and .17 patients (27%) have died of progressive MM. The probabilities of survival and relapse-freesurvival at 3 years for the 19 patients who achieved a CR were .42 and .17, respectively. In the multivariate analysis, beta(2)-microglobulin levels more than 2.5 mu g/mL, more than two regimens of prior therapy and eight cycles of treatment, time to transplant longer than 3 years from diagnosis, and prior radiation were associated with adverse outcomes. Additional strategies, such as intervention earlier in the disease course, improved treatment regimens, sequential high-dose treatments, and posttransplant therapies may improve outcome of selected patients with MM. (C) 1996 by American Society of Clinical Oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:40:07