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Titolo:
EXCIMER-LASER INDUCED BUBBLE - DIMENSIONS, THEORY, AND IMPLICATIONS FOR LASER ANGIOPLASTY
Autore:
VANLEEUWEN TG; JANSEN ED; WELCH AJ; BORST C;
Indirizzi:
UNIV UTRECHT HOSP,EXPT CARDIOL LAB,DEPT CARDIOL,HEART LUNG INST,ROOM G02523,POB 85500 3508 GA UTRECHT NETHERLANDS
Titolo Testata:
Lasers in surgery and medicine
fascicolo: 4, volume: 18, anno: 1996,
pagine: 381 - 390
SICI:
0196-8092(1996)18:4<381:EIB-DT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE ABLATION;
Keywords:
XENON-CHLORIDE EXCIMER LASER; PULSED LASER; VAPORIZATION; CAVITATION; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T.G. Vanleeuwen et al., "EXCIMER-LASER INDUCED BUBBLE - DIMENSIONS, THEORY, AND IMPLICATIONS FOR LASER ANGIOPLASTY", Lasers in surgery and medicine, 18(4), 1996, pp. 381-390

Abstract

Background and Objective: Previous studies have demonstrated that during Xenon-Chloride excimer laser ablation of tissue, rapidly expandingand imploding bubbles (diameter < 3 mm), predominantly containing water vapor, are formed. These short lived bubbles (Life time < 300 mu s)induce mechanical damage in adjacent tissue. In the present study, a theoretical analysis of the volume of vaporized water is correlated with measured bubble volumes formed in hemoglobin solution. Study Design/Materials and Methods: The dimensions of the rapidly expanding and imploding vapor bubble induced by the XeCl excimer laser pulses (308 nn,115 ns), delivered via a 300, 550, or 950 mu m diameter monofiber in 16% w/v hemoglobin solution (at 37 degrees C), were measured. Results:Theoretical analysis and the experimental data correlated well (correlation coefficient r = 0.97). The diameter of excimer laser induced bubbles increased with increasing pulse energy. For a given radiant exposure, the bubble size was decreased by either decreasing the fiber tiparea or by decreasing the absorption coefficient of the hemoglobin solution. Conclusion: We conclude that, for a wide range of conditions, theory agrees well with experimental data. Thus, during delivery of excimer laser pulses in blood, bubble dimensions can be reduced by flushing with saline or by reduction of the area radiated with each laser pulse, for example, by pulse multiplexing or using a smaller multifibercatheter. (C) 1996 Wiley-Liss, Inc.

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Documento generato il 02/12/20 alle ore 14:39:48