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Titolo:
THROMBOXANE ANTAGONISM IN EXPERIMENTAL CANINE CAROTID-ARTERY THROMBOSIS
Autore:
ROTE WE; MU DX; LUCCHESI BR;
Indirizzi:
UNIV MICHIGAN,SCH MED,DEPT PHARMACOL,M6322 MED SCI BLDG I ANN ARBOR MI 48109 UNIV MICHIGAN,SCH MED,DEPT PHARMACOL,M6322 MED SCI BLDG I ANN ARBOR MI 48109
Titolo Testata:
Stroke
fascicolo: 6, volume: 24, anno: 1993,
pagine: 820 - 828
SICI:
0039-2499(1993)24:6<820:TAIECC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE PLASMINOGEN-ACTIVATOR; CORONARY THROMBOLYSIS; PLATELET ACTIVATION; INVIVO; BIOSYNTHESIS; REOCCLUSION; BAY-U-3405; SYNTHASE; ASPIRIN; RABBIT;
Keywords:
PLATELET AGGREGATION; THROMBOSIS; THROMBOXANE ANTAGONISTS; DOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
W.E. Rote et al., "THROMBOXANE ANTAGONISM IN EXPERIMENTAL CANINE CAROTID-ARTERY THROMBOSIS", Stroke, 24(6), 1993, pp. 820-828

Abstract

Background and Purpose: The two objectives of this study were to assess the potential of BAY U 3405 to prevent arterial thrombosis in response to vessel wall injury and to determine the ability of BAY U 3405 to prevent thrombotic reocclusion after thrombolysis with anisoylated plasminogen streptokinase activator complex. Methods: Dogs were instrumented with a carotid flow probe, stimulating electrode, and a stenosis. Current (150 muA) was applied to the intimal surface of the right carotid artery, and time to occlusive thrombus formation was noted. BAY U 3405 was administered, and the procedure for thrombus formation was repeated for the left carotid artery. Results: BAY U 3405 administration prevented occlusive arterial thrombosis formation. Ex vivo plateletaggregation was inhibited, bleeding time increased, and thrombus weight reduced after BAY U 3405 treatment. In a second group, thrombi wereformed initially in both carotid arteries, BAY U 3405 was administered as before, and anisoylated plasminogen streptokinase activator complex was infused in the right carotid artery proximal to the occlusive thrombus. BAY U 3405 did not after the incidence of rethrombosis compared with the lytic agent alone. Conclusions: BAY U 3405 prevented primary arterial thrombosis, corresponding to inhibition of platelet aggregation, and increased bleeding times. BAY U 3405, however, did not prevent rethrombosis after successful thrombolysis with anisoylated plasminogen streptokinase activator complex, despite the fact that platelet reactivity was inhibited. The data are consistent with the concept that the residual thrombus represents a more effective thrombogenic stimulus as compared with arterial wall injury alone and that the mechanisms associated with primary versus secondary thrombus formation may require separate therapeutic approaches.

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Documento generato il 04/12/20 alle ore 03:56:18