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Titolo:
EFFECT OF AGE ON STRETCH-INDUCED SECRETION OF ATRIAL NATRIURETIC
Autore:
ZHANG YL; KAUFMAN S;
Indirizzi:
UNIV ALBERTA,DEPT MED,475 HERITAGE MED RES CTR EDMONTON AB T6G 2S2 CANADA UNIV ALBERTA,DEPT MED EDMONTON AB T6G 2S2 CANADA
Titolo Testata:
Canadian journal of physiology and pharmacology
fascicolo: 2, volume: 74, anno: 1996,
pagine: 132 - 136
SICI:
0008-4212(1996)74:2<132:EOAOSS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANF RELEASE; PEPTIDE; RAT; RESPONSES; HUMANS; YOUNG;
Keywords:
ISOLATED ATRIUM; ATRIAL NATRIURETIC FACTOR; RAT; HYPERVOLEMIA; ATRIAL COMPLIANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
Y.L. Zhang e S. Kaufman, "EFFECT OF AGE ON STRETCH-INDUCED SECRETION OF ATRIAL NATRIURETIC", Canadian journal of physiology and pharmacology, 74(2), 1996, pp. 132-136

Abstract

Plasma atrial natriuretic factor (ANF)? levels are known to be higherin aged rats and humans. Although this may be partially explained by a reduction in clearance from the circulation, it was not known whether the secretory nature of the atrial tissue also changes with age. We measured ANF release in response to atrial distention in young adult (2-3 months) and older retired breeder (4-6 months) male rats both in vivo (conscious instrumented animals) and in vitro (isolated perfused atria). Whereas increased intraluminal pressure caused a rise in ANF secretion when using atria derived from the younger rats, there was no such response when using atria derived from the older rats, i.e., stretch-induced secretion was impaired. This appeared to be secondary to a reduction in atrial compliance in the older animals. Unlike previous studies, basal plasma ANF levels were lower in our retired breeders, although the response to volume lending was preserved. These results suggest that, already by about 6 months of age, the atrial tissue is lessresponsive to changes in atrial pressure. The increased plasma levelspreviously reported in senescent rats are therefore probably a resultof reduced clearance rather than increased secretion.

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Documento generato il 02/07/20 alle ore 22:23:55