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Titolo:
HIPPOCAMPAL AFFERENTS TO THE RAT PREFRONTAL CORTEX - SYNAPTIC TARGETSAND RELATION TO DOPAMINE TERMINALS
Autore:
CARR DB; SESACK SR;
Indirizzi:
UNIV PITTSBURGH,DEPT NEUROSCI,446 CRAWFORD HALL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT NEUROSCI PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PSYCHIAT PITTSBURGH PA 15260
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 369, anno: 1996,
pagine: 1 - 15
SICI:
0021-9967(1996)369:1<1:HATTRP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS-SEPTI; CEREBRAL-CORTEX; HORSERADISH-PEROXIDASE; DENDRITIC SPINES; ADULT-RAT; AXON TERMINALS; VISUAL-CORTEX; AMYGDALOID PROJECTIONS; ELECTRICAL-PROPERTIES; RETROGRADE TRANSPORT;
Keywords:
PRELIMBIC CORTEX; INFRALIMBIC CORTEX; HIPPOCAMPUS; SUBICULUM; ULTRASTRUCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
93
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Carr e S.R. Sesack, "HIPPOCAMPAL AFFERENTS TO THE RAT PREFRONTAL CORTEX - SYNAPTIC TARGETSAND RELATION TO DOPAMINE TERMINALS", Journal of comparative neurology, 369(1), 1996, pp. 1-15

Abstract

Afferents to the prefrontal cortex (PFC) from the hippocampal formation and from midbrain dopamine (DA) neurons have been implicated in thecognitive and adaptive functions of this cortical region. In the present study, we investigated the ultrastructure and synaptic targets of hippocampal terminals, as well as their relation to DA terminals within the PFC of adult rats. Hippocampal afferents were labeled either by anterograde transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) from the ventral hippocampal formation or by anterograde degeneration following fimbria lesion. Hippocampal terminals in the PFC, identified by either method, formed primarily asymmetric axospinous synapses, with a small percentage forming asymmetric axodendritic synapses. Dopamine terminals in the PFC were identified by peroxidase immunocytochemistry for either tyrosine hydroxylase or DA and formed primarily symmetric synapses onto dendritic spines and small caliber dendritic shafts. Spines that received symmetric synaptic contact from DA terminals invariably also received an asymmetric synapse from an unlabeledterminal, forming a triadic complex. Hippocampal and DA terminals in the PFC were not often observed in the same area of the neuropil, and no examples of convergence of hippocampal and DA terminals onto commonpostsynaptic targets were observed. Further analysis revealed that spines receiving synaptic contact from hippocampal terminals did not receive additional synaptic contact from any other source. However, when localized to the same area of the neuropil, hippocampal and DA terminals were often in direct apposition to one another, without forming axo-axonic synapses. These results suggest that 1) hippocampal terminals primarily form excitatory synapses onto spiny pyramidal neurons, 2) hippocampal afferents are unlikely to be synaptically modulated by DA ornon-DA terminals at the level of the dendritic spine, and 3) appositions between hippocampal and DA terminals may facilitate presynaptic interactions between these afferents to the PFC. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:09:49