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Titolo:
INHIBITION OF VEIN GRAFT INTIMAL AND MEDIAL THICKENING BY PERIADVENTITIAL APPLICATION OF A SULFATED CARBOHYDRATE POLYMER
Autore:
TOES GT; BARNATHAN ES; LIU HG; RAGHUNATH PN; TOMASZEWSKI JE; CARON RJ; WEISZ PB; VANOEVEREN W; GOLDEN MA;
Indirizzi:
HOSP UNIV PENN,DEPT SURG,3400 SPRUCE ST,SILVERSTEIN 4 PHILADELPHIA PA19104 UNIV GRONINGEN HOSP,CARDIOTHORAC SURG RES DIV GRONINGEN NETHERLANDS UNIV PENN,SCH MED,DEPT BIOENGN PHILADELPHIA PA 19104 UNIV PENN,DEPT PATHOL PHILADELPHIA PA 19104 UNIV PENN,DEPT SURG MED PHILADELPHIA PA 19104
Titolo Testata:
Journal of vascular surgery
fascicolo: 4, volume: 23, anno: 1996,
pagine: 650 - 656
SICI:
0741-5214(1996)23:4<650:IOVGIA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE CELL-PROLIFERATION; BETA-CYCLODEXTRIN TETRADECASULFATE; GROWTH-FACTOR FAMILY; HEPARIN; HYPERPLASIA; PATHOGENESIS; REDUCTION; ARTERIES; KINETICS; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G.T. Toes et al., "INHIBITION OF VEIN GRAFT INTIMAL AND MEDIAL THICKENING BY PERIADVENTITIAL APPLICATION OF A SULFATED CARBOHYDRATE POLYMER", Journal of vascular surgery, 23(4), 1996, pp. 650-656

Abstract

Purpose: The purpose of this study was to determine whether the wall thickening observed in vein grafts after they were placed into the arterial circulation could be inhibited by periadventitial delivery of aninsoluble sulfated polymer of beta-cyclodextrin (P-CDS) capable of tightly binding heparin binding growth factors. Methods: Thirty-four NewZealand white rabbits underwent implantation of reversed autologous jugular vein interposition grafts in the common carotid artery and wererandomized to receive either 20 mg P-CDS (n = 18) topically around the graft or no additional therapy (n = 16). Before being killed at 28 days, animals were given bromodeoxyuridine to assess smooth muscle cellproliferation. Histomorphometric analyses were performed after perfusion fixation. Results: Compared to controls, treatment with P-CDS was associated with reduced mean intimal thickness (24 +/- 3 vs 38 +/- 4 mu m; mean +/- SEM, p < 0.01) and intimal area (0.25 +/- 0.03 vs 0.54 +/- 0.09 mm(2); P < 0.01). There was also significantly less medial thickness in the P-CDS group (45 +/- 3 vs 63 +/- 3, P < 0.001). There wasno significant difference in intimal or medial smooth muscle cell proliferation between P-CDS-treated and control vein grafts at 28 days. The polymer persisted in the adventitia with a mild foreign body reaction. Conclusion: Periadventitial placement of P-CDS, a novel, insoluble, sulfated carbohydrate polymer, inhibits intimal and medial thickening of vein bypass grafts in this model of vein grafting. The persistence of P-CDS in vivo for prolonged periods, and the ease of topical application of P-CDS during vascular bypasses may have important implications for its future use in vascular surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:06:37