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Titolo:
CONDITIONS SUFFICIENT FOR THE PRODUCTION OF ORAL COCAINE OR LIDOCAINESELF-ADMINISTRATION IN PREFERENCE TO WATER
Autore:
FALK JL; SIRIS A; LAU CE;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903
Titolo Testata:
Drug and alcohol dependence
fascicolo: 3, volume: 40, anno: 1996,
pagine: 241 - 247
SICI:
0376-8716(1996)40:3<241:CSFTPO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADMINISTERED COCAINE; RHESUS-MONKEYS;
Keywords:
COCAINE SELF-ADMINISTRATION; SCHEDULE-INDUCED BEHAVIOR; ORAL COCAINE LIDOCAINE; STIMULUS CONTROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Falk et al., "CONDITIONS SUFFICIENT FOR THE PRODUCTION OF ORAL COCAINE OR LIDOCAINESELF-ADMINISTRATION IN PREFERENCE TO WATER", Drug and alcohol dependence, 40(3), 1996, pp. 241-247

Abstract

Groups of rats were given a chronic history of drinking cocaine solutions of different concentrations in daily, 3-h schedule-induced polydipsia sessions. Animals failed to develop a preference for cocaine solution to concurrently presented water. Schedule-induction conditions were maintained, and the animals were divided into separate groups, drinking either cocaine or lidocaine placed in a highly acceptable vehicle(glucose-saccharin solution). Animals preferred their respective drugsolutions to concurrently presented water, and these preferences remained stable after the glucose-saccharin vehicle was gradually faded towater, leaving only cocaine or lidocaine, respectively, in the solution. Thus a stable preference for drug solution to water could be instituted in rats for either cocaine or lidocaine solution (putative reinforcing and nonreinforcing agents, respectively) given an appropriate associative history, with high intakes maintained by schedule-induction. Conditions sufficient for the initiation of an oral preference and high intake for a putatively reinforcing drug cannot be assumed to occur owing to the drug's reinforcing property in the absence of demonstrating the ineffectiveness of an appropriate negative control substance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:47:27