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Titolo:
EFFECT OF TREATMENT DURATION ON PLASMA-LEVELS OF CLOZAPINE AND N-DESMETHYLCLOZAPINE IN MEN AND WOMEN
Autore:
FABRAZZO M; ESPOSITO G; FUSCO R; MAJ M;
Indirizzi:
UNIV NAPLES,SCH MED 1,DEPT PSYCHIAT,LARGO MADONNA GRAZIE I-80138 NAPLES ITALY
Titolo Testata:
Psychopharmacology
fascicolo: 1-2, volume: 124, anno: 1996,
pagine: 197 - 200
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE OXIDATION; SCHIZOPHRENIC-PATIENTS; LIQUID-CHROMATOGRAPHY; NORCLOZAPINE; SMOKING; SERUM;
Keywords:
CLOZAPINE; N-DESMETHYLCLOZAPINE; CLOZAPINE-N-OXIDE; SEX; PLASMA LEVELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
M. Fabrazzo et al., "EFFECT OF TREATMENT DURATION ON PLASMA-LEVELS OF CLOZAPINE AND N-DESMETHYLCLOZAPINE IN MEN AND WOMEN", Psychopharmacology, 124(1-2), 1996, pp. 197-200

Abstract

Plasma levels of clozapine and its major metabolites, N-desmethylclozapine and clozapine-N-oxide, were measured in 18 schizophrenic patients at different times (4, 6 and 24 weeks) during the course of treatment with multiple doses of the drug, by using high performance liquid chromatography (HPLC) with UV detection. Plasma levels of clozapine and N-desmethylclozapine were significantly higher in females than in males after 4 and 6 weeks, but not after 24 weeks, of treatment. No sex difference was found at any time with respect to plasma levels of clozapine-N-oxide.

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Documento generato il 27/01/20 alle ore 13:55:40