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Titolo:
MECHANISMS OF ACTION OF ATYPICAL ANTIPSYCHOTIC-DRUGS - A CRITICAL ANALYSIS
Autore:
KINON BJ; LIEBERMAN JA;
Indirizzi:
LONG ISL JEWISH MED CTR,HILLSIDE HOSP,DEPT PSYCHIAT,ALBERT EINSTEIN COLL MED,POB 38 GLEN OAKS NY 11004
Titolo Testata:
Psychopharmacology
fascicolo: 1-2, volume: 124, anno: 1996,
pagine: 2 - 34
Fonte:
ISI
Lingua:
ENG
Soggetto:
HALOPERIDOL-INDUCED CATALEPSY; MIDBRAIN DOPAMINE NEURONS; METHYL-D-ASPARTATE; C-FOS EXPRESSION; NEUROLEPTIC-INDUCED CATALEPSY; CHRONIC CLOZAPINE TREATMENT; MEDIAL PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS-SEPTI; MESSENGER-RNA LEVELS; FREELY MOVING RATS;
Keywords:
REVIEW; ATYPICAL ANTIPSYCHOTIC DRUG; SCHIZOPHRENIA; CLOZAPINE; HALOPERIDOL; CATALEPSY; EXTRAPYRAMIDAL SYMPTOMS; TARDIVE DYSKINESIA; DOPAMINE RECEPTOR; BIOGENIC AMINES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
516
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Kinon e J.A. Lieberman, "MECHANISMS OF ACTION OF ATYPICAL ANTIPSYCHOTIC-DRUGS - A CRITICAL ANALYSIS", Psychopharmacology, 124(1-2), 1996, pp. 2-34

Abstract

Various criteria used to define atypical antipsychotic drugs include:1) decrease, or absence, of the capacity to cause acute extrapyramidal motor side effects (acute EPSE) and tardive dyskinesia (TD); 2) increased therapeutic efficacy reflected by improvement in positive, negative, or cognitive symptoms; 3) and a decrease, or absence. of the capacity to increase prolactin levels. The pharmacologic basis of atypicalantipsychotic drug activity has been the target of intensive study since the significance of clozapine was first appreciated. Three notionshave been utilized conceptually to explain the distinction between atypical versus typical antipsychotic drugs: 1) dose-response separationbetween particular pharmacologic functions; 2) anatomic specificity of particular pharmacologic activities; 3) neurotransmitter receptor interactions and pharmacodynamics. These conceptual bases are not mutually exclusive, and the demonstration of limbic versus extrapyramidal motor functional selectivity is apparent within each arbitrary theoretical base. This review discusses salient distinctions predominantly between prototypic atypical and typical antipsychotic drugs such as clozapine and haloperidol, respectively. In addition, areas of common function between atypical and typical antipsychotic drug action may also be crucial to our identification of pathophysiological foci of the different dimensions of schizophrenia, including positive symptoms, negativesymptoms, and neurocognitive deficits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:34:47