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Titolo:
A STABLE MODEL OF RESPIRATORY-DISTRESS BY SMALL INJECTIONS OF OLEIC-ACID IN PIGS
Autore:
GROTJOHAN HP; VANDERHEIJDE RMJL; JANSEN JRC; WAGENVOORT CA; VERSPRILLE A;
Indirizzi:
ERASMUS UNIV,DEPT PULM DIS,PATHOPHYSIOL LAB,POB 1738 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV,DEPT PULM DIS,PATHOPHYSIOL LAB 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT PATHOL 3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Intensive care medicine
fascicolo: 4, volume: 22, anno: 1996,
pagine: 336 - 344
SICI:
0342-4642(1996)22:4<336:ASMORB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY-EDEMA; INDUCED LUNG INJURY; MECHANICAL VENTILATION; CARDIAC-OUTPUT; PRESSURE; PERMEABILITY; DEFINITION; SHEEP; CA-2+; DOGS;
Keywords:
OLEIC ACID; LUNG INJURY; RESPIRATORY DISTRESS; ALBUMINE; BOLUS INJECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
H.P. Grotjohan et al., "A STABLE MODEL OF RESPIRATORY-DISTRESS BY SMALL INJECTIONS OF OLEIC-ACID IN PIGS", Intensive care medicine, 22(4), 1996, pp. 336-344

Abstract

Objective. Development of a stable model of respiratory distress in pigs with oleic acid, fulfilling clinical criteria of the adult respiratory distress syndrome (ARDS). Design. Eight pigs (9.1 +/- 0.7 kg) were anesthetized with pentobarbital, paralyzed with tubocurarine and mechanically ventilated with an F-IO2 Of 0.6, an I:E ratio of 2.3 and a PEEP of 0.2 kPa. Oleic acid (dissolved 1.1 in 96% alcohol) was administered in a series of multiple injections of 0.1 mi until P-aO2 was lower than 8 kPa. Measurements and results: Careful titration of the oleicacid injections on guidance of the P-aO2 established a reproducible respiratory distress (P-aO2 = 7.3 +/- 0.8 kPa), in which gas exchange and hemodynamic variables were stable for at least 4 h. The number of oleic acid injections (22 +/- 11, mean and SD) varied between the animals. Conclusions: With the use of multiple injections of oleic acid, a stable model of early respiratory distress in pigs can be achieved, inspite of individual differences in sensitivity. Such a stable model allows for a diversity of studies on early respiratory distress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:03:07