Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MORPHOLOGICAL-CHANGES IN MET(5)-ENKEPHALIN-IMMUNOREACTIVE SYNAPTIC BOUTONS IN THE RAT NEOSTRIATUM AFTER HALOPERIDOL DECANOATE TREATMENT
Autore:
MIJNSTER MJ; INGHAM CA; MEREDITH GE; DOCTOR GJ; ARBUTHNOTT GW;
Indirizzi:
FREE UNIV AMSTERDAM,FAC MED,DEPT ANAT & EMBRYOL,GRAD SCH NEUROSCI AMSTERDAM,RES INST NEUROSCI 1081 BT AMSTERDAM NETHERLANDS UNIV EDINBURGH,DEPT PRECLIN VET SCI EDINBURGH EH9 1QH MIDLOTHIAN SCOTLAND
Titolo Testata:
European journal of neuroscience
fascicolo: 4, volume: 8, anno: 1996,
pagine: 716 - 726
SICI:
0953-816X(1996)8:4<716:MIMSB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROENKEPHALIN MESSENGER-RNA; LONG-TERM TREATMENT; INSITU HYBRIDIZATION; SUBSTANTIA NIGRA; DOPAMINERGIC REGULATION; ULTRASTRUCTURAL-CHANGES; ENKEPHALIN RELEASE; NEUROLEPTIC DRUGS; GENE-EXPRESSION; MET-ENKEPHALIN;
Keywords:
ANTIPSYCHOTIC DRUGS; SYNAPTIC SHAPE; ELECTRON MICROSCOPY; BASAL GANGLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Mijnster et al., "MORPHOLOGICAL-CHANGES IN MET(5)-ENKEPHALIN-IMMUNOREACTIVE SYNAPTIC BOUTONS IN THE RAT NEOSTRIATUM AFTER HALOPERIDOL DECANOATE TREATMENT", European journal of neuroscience, 8(4), 1996, pp. 716-726

Abstract

The morphological plasticity of an identified population of synaptic boutons in the rat neostriatum was investigated 24 h (short-term treatment) or 14 days (long-term treatment) after administration of the depot neuroleptic, haloperidol decanoate. Specific methionine(5)-enkephalin antiserum was used to label bouton profiles in the dorsal neostriatum. The size and shape of these boutons was subsequently analysed withquantitative methods at the ultrastructural level. Immunoreactive synaptic bouton profiles were found to have a larger cross-sectional area, to be less circular in shape and to have a longer maximum diameter after long-term neuroleptic treatment. These parameters were not significantly affected by short-term neuroleptic treatment. The morphological parameters indicate that methionine(5)-enkephalin-immunoreactive boutons become enlarged, probably by elongating. This suggests that boutons containing methionine(5)-enkephalin increase their potential synaptic efficacy in the long term after neuroleptic treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:04:12