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Titolo:
SUPPLEMENTAL IMMUNE GLOBULINS IN SEPSIS - A CRITICAL-APPRAISAL
Autore:
WERDAN K; PILZ G;
Indirizzi:
UNIV HALLE WITTENBERG,INNERE MED KLIN 3,KLINIKUM KROLLWITZ,ERNST GRUBE STR 40 D-06120 HALLE GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN W-8000 MUNICH GERMANY
Titolo Testata:
Clinical and experimental immunology
, volume: 104, anno: 1996, supplemento:, 1
pagine: 83 - 90
SICI:
0009-9104(1996)104:<83:SIGIS->2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED CLINICAL-TRIAL; GRAM-NEGATIVE BACTEREMIA; SEPTIC SHOCK; IMMUNOGLOBULIN THERAPY; BACTERIAL-INFECTIONS; SURGICAL PATIENTS; DOUBLE-BLIND; PLACEBO; MULTICENTER; PROPHYLAXIS;
Keywords:
IVIG; SEPSIS; APACHE II SCORE; CARDIAC SURGERY; SBITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
K. Werdan e G. Pilz, "SUPPLEMENTAL IMMUNE GLOBULINS IN SEPSIS - A CRITICAL-APPRAISAL", Clinical and experimental immunology, 104, 1996, pp. 83-90

Abstract

For 'the total population of patients with sepsis, sepsis syndrome orSIRS', the question of whether intravenous immune globulin (IVIG) reduces mortality is neither proved nor disproved. For the sepsis subgroups 'postoperative sepsis with a sepsis score > 19' and 'endotoxaemic, early septic shock', a significant reduction in mortality by IVIG has been documented in a single, placebo-controlled, small trial of each subgroup; subsequent studies are needed for cofirmation. The incidence of some severe infections in defined 'patients at risk' and 'operations at risk' is lowered by IVIG prophylaxis. Postoperative APACHE II-score identification of high-risk cardiac surgery patients prone to sepsis and severe SIRS may represent one approach to optimize individual, early therapy. Applying this concept to immune globulin treatment in a pilot study, the administration of IgG-IVIG and IgGMA-IVIG yielded similar results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:39:55